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Pharma; Re 2 > CNS drugs 3: Antidepressants > Flashcards

CNS drugs 3: Antidepressants Flashcards

1
Q

Major classification under antidepressants

A 
MAO inhibitors
TCA
heterocyclic antidepressants
SNRI
SSRI
serotonin antagonists
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2
Q

representatives for MAOi

A

Phenelzine
Selegiline
Tranylcypromine

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3
Q

representatives of TCA

A

Amitriptyline
Clomipramine
Imipramine

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4
Q

reps of HCA

A

amoxapine
BUPOPRION
mirtazapine

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5
Q

reps of SSRI

A 
Fluoxetine
Fluvoxamine
Escitalopram
Paroxetine
Sertraline
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6
Q

reps of SNRI

A

Duloxetine

Venlafaxine

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7
Q

reps of serotonin antagonists

A

Nefazodone

Trazodone

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8
Q

TCA overdose

A

3 Cs
†Cardiotoxicity
Convulsions
Coma

†cardiotoxicity reversed by BICARBONATE

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9
Q

TCA drugs

A

Imipramine
Amitryptyline
Doxepin

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10
Q

SSRI drugs

A 
Paroxetine
Fluoxetine
†Fluvoxamine
Escitalopram
ªCitalopram
Sertraline
Vilazodone

†fluvoxamine is approved only for obsessive-compulsive behavior

ªcitalopram: QT prolongation and teratogen (cardial septal defects)

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11
Q

SNRI drugs

A

Duloxetine
Venlafaxine
Desvenlafaxine
Milnacipran

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12
Q

Serotonin antagonist drugs

A

†trazodone
nefazodone
vortioxetine

(blocks 5-HT2A

†trazodone causes priapism

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13
Q

tetracyclic antidepressants

A

amoxapine
maprotiline
mirtazapine

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14
Q

antidepressant used for smoking cessation

A

BUPOPRION
-also used for refractory MDD, alcohol dependence

MOA: inhibits neuronal reuptake of dopamine and norepinephrine
-no effect on 5HT or NE receptors or amine transporters

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15
Q

MAOi drugs

A

Selegiline
Phenelzine
Isocarboxazid
Tranylcypromine

inhibits MAO A and B

Selegiline is MAO-B selective inhibitor

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16
Q

SSRI inhibitors of CYP450

A

fluoxetine
fluvoxamine
Paroxetine

17
Q

incresed risk for suicide in children and adolescnets

A

snri

18
Q

Used uff-label for hypnosis

A

trazodone

19
Q

antidepressants not assoc’d with sexual dysfxn

A

mirtazapine (TTCA)
Bupoprion (DNRI)
nefazodone (SA)

20
Q

lowers seizure threshold

A

TCA

21
Q

may be given as skin patch

A

selegiline

22
Q

releasers of norepi from rpresynaptic vesicles

A

TAE
Tyramine
Amphetamine
Ephedrine

23
Q

drugs that can cause erectile dysfxn and priapism

A

ERECTILE DYSFXN
SSRI
Hydrochlorothiazide

PRIAPISM
Bupoprion
Warfarin
Trazodone
Quitiapine
24
Q

first-line tx of neuroleptic malignant syndrome

A

DIPHENHYDRAMINE

NMS
-due to antipsychotics (DOPAMINE ANTAGONISM)

“FEVER”
Fever
Encephalopathy
Vitals unstable
Elevated CPK
Rigidity
25
Q

drugs with effects on QT interval

A

QT prolongation
Ziprasidone
Citalopram

QT shortening
Digoxin

Pharma; Re 2 (12 decks)

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