Clotting Cascade

Question 1

What is the MOA of Warfarin?

Answer 1

It decreases the amount of active Vitamin K, which is required by gamma-glutamylcarboxylase, due to its ability to inhibit epoxide hydrolase

Question 2

What clotting factors does Warfarin inhibit?

Answer 2

II, VII, IX, X, and proteins C and S

Question 3

How long after giving warfarin is its full effect seen?

Answer 3

Not for 48 hours

Question 4

Is the extrinsic or intrinsic pathway quicker acting?

Answer 4

Extrinsic

Question 5

What activates the extrinsic pathway?

Answer 5

External damage

Question 6

What activates the intrinsic pathway?

Answer 6

Intrinsic damage

Question 7

What is the primary difference between primary and secondary hemostasis?

Answer 7

Secondary makes a stronger plug by generating a fibrin mesh on the primary plug

Question 8

What is vitamin K used for in a clinical setting?

Answer 8

It is given to patients with mucosal bleeding to overcome to effects of Warfarin

Question 9

What is the time frame for administration of tPA for stroke?

Answer 9

Within 3 hours of onset of symptoms