Clostridium Difficile

Question 1

What factors cause immune system to overlook C. diff?

Answer 1

Spores of C. diff are apart of the normal flora in the gut. They do not pose a threat unless the normal bacterial flora of the colon is disrupted.

(Which in this case is C. diff).

Question 2

Pathophysiology of C. diff?

Answer 2

1. Spores are apart of normal flora in the gut.
2. Use of antibiotics can kill “good” bacteria - leading to a lowered resistance to a C. diff bacteria.
3. When normal flora of gut is eradicated, this provides C. diff bacteria a proper environment to multiply and produce its toxins.
4. Release of toxins -> mucosal damage, inflammation.

Question 3

What are the resistance issues with C. diff?

Answer 3

–

Question 4

What is the trend of mortality with C. diff?

Answer 4

C. diff causes diarrhea linked to 14,000 US deaths each year.

Question 5

• How do you get C. Diff?

Answer 5

• Overuse of antibiotics.
• Weak immune system from chronic major illness.
• Women > 65
• Prolonged use of antibiotics

Question 6

• How do you prevent C. Diff?

Answer 6

• Isolation.
• Take entire antibiotic treatment.
• Wear disposable PPE, hand hygiene, clean products