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Microbiology 2: Mycology and Virology > Clinical Virology > Flashcards

Clinical Virology Flashcards

0
Q

(T/F) Viruses are obligate intracellular parasites

A

T

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1
Q

Give 4 characteristics of a virus.

A

Obligate intracellular parasite
Cannot multiply by binary fission
Can’t generate ATP
Lack ribosomal RNA

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2
Q

(T/F) Viruses multiply through binary fission

A

F

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3
Q

Viruses generate ATP

A

F

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4
Q

Viruses have ribosomal RNA

A

F

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5
Q

Enumerate the structural components of a virus

A 
Virion (virus particle)
Nuclei acid: DNA or RNA
Nucleocapsid (Enveloped nucleocapsid/Naked nucleocapsid)
Envelope
Capsid (protein coat)
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6
Q

This is the structural component of a virus that is also known as the virus particle.

A

Virion

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7
Q

This is the structural component of a virus that is also known as the protein coat.

A

Capsid

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8
Q

The protein coat or capsid, is composed of _____.

A

Capsomer

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9
Q

This is also known as the protein subunit.

A

Capsomer

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10
Q

(T/F) the nucleic acid of a virus is composed of a DNA and an RNA

A

F

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11
Q

This is the structural component of a virus that functions as the outer membrane. It is a phospholipid bilayer that is composed of a glycoprotein and a matrix portion

A

Envelope

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12
Q

The phospholipid bilayer of the envelope is composed of _____ and _____.

A

Glycoprotein

Matrix portion

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13
Q

This is the part of the phospholipid bilayer in the envelope that spikes for attachment to host

A

Glycoprotein

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14
Q

This is the part of the phospholipid bilayer in the envelope that connects the envelope to the capsid

A

Matrix portion

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15
Q

_____ is a nucleocapsid with an envelope and _____ is a nucleocapsid without an envelope

A

Enveloped nucleocapsid

Naked nucleocapsid

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16
Q

What are the basis of taxonomy for viruses?

A

Type of genome
Strandedness of genome
Capsid morphology
Presence and absence of capsule

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17
Q

What are the steps in viral replication?

A 
Adsorption
Penetration
Uncoating
Eclipse stage
Assembly/Maturation
Release
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18
Q

This is the step in viral replication wherein attachment to host cell occurs.

A

Adsorption

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19
Q

What are the three methods of the penetration step of viral replication?

A

Direct injection - Naked virions
Fusion with cell membrane
Endocytosis - enveloped virus enters cell in a cytoplasmic vacuole

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20
Q

This is the step in viral replication wherein the capsid is loose exposing the genome

A

Uncoating

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21
Q

This is the step in viral replication wherein there is genome replication and expression

A

Eclipse stage

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22
Q

This is the step in viral replication wherein the genetic material packs into the capsid

A

Assembly/Maturation

23
Q

This is the step in viral replication wherein there is budding or lysis of the host cell

24
Q

In the lab diagnosis of viruses, what are to be considered when collecting the specimen?

A 
Collected in early stage
Sample in actual infected site
Use transport medium (Hank's)
Swabs (cotton in plastic shafts)
Aspirate (without transport medium)
Store at 4 C (short term), -70 C (long term)
25
Q

At what stage of the disease should the sample be collected?

A

Early stage

26
Q

What transport medium should be used for viruses?

27
Q

What type of swabs should be used when collecting viruses?

A

Cotton in plastic shaft

28
Q

A temperature of ___ C should be used when storing a virus sample for a short term only.

29
Q

A temperature of ___ C should be used when storing a virus sample for a long.

30
Q

What is the manifestation of a virus infection when the body system infected is the CNS?

A

Encephalitis

Aseptic meningtis

31
Q

What is the manifestation of a virus infection when the body system infected are multiple organs?

A

Viremia (virus in the blood)

32
Q

This is a term used to describe a disease spreading through multiple organs.

A

Disseminated

33
Q

What is the manifestation of a virus infection when the body system infected is the ocular system?

A

Conjunctivitis

Keratitis

34
Q

What is the manifestation of a virus infection when the body system infected is the respiratory tract?

A

Croup.?????
Bronchiolitis
Pneumonia

35
Q

What is the manifestation of a cutaneous virus infection?

A

Lesions

Exanthems (rashes)

36
Q

What is the manifestation of a genital virus infection?

A

Urethritis, etc.

Penile lesions

37
Q

What is the manifestation of a virus infection when the body system infected is the gastrointestinal system?

A

Gastroenteritis

38
Q

What is the manifestation of a congenital virus infection?

A

Lesions

Exanthems (rashes)

39
Q

What is the specimen used for a virus infection when the body system infected is the CNS?

A

CSF
Brain biopsy
Nasopharynx (NP) Swabs

40
Q

What is the specimen used for a disseminated virus infection?

A

EDTA whole blood
Serum
Urine

41
Q

What is the specimen used for an ocular virus infection?

A

Conjunctival scrapings

Corneal swabs

42
Q

What is the specimen used for a respiratory tract virus infection?

A

Nasal aspirate
Nasopharynx (NP) swabs
Throat swabs
BAL

43
Q

What is the specimen used for a cutaneous virus infection?

A

Vesicle aspirate

Lesion swab

44
Q

What is the specimen used for a genital virus infection?

A

Vesicle aspirate

Swabs

45
Q

What is the specimen used for a gastrointestinal virus infection?

A

Stool

Rectal swab

46
Q

What is the specimen used for a congenital virus infection?

A

Throat
Urine
Serum

47
Q

What are the viruses to be considered for a CNS virus infection?

A 
HHV 1-3
Arbo
Entero
Echo
Mumps
48
Q

What are the viruses to be considered for a disseminated virus infection?

A

HHV 1-4
HBV
Arbo

49
Q

What are the viruses to be considered for a ocular virus infection?

A

HHV 1-4

Adeno

50
Q

What are the viruses to be considered for a respiratory tract virus infection?

A 
HHV 1-5
Influenza
P/V
PSV
Adeno
51
Q

What are the viruses to be considered for a cutaneous virus infection?

A

HHV 1-7 (ex. EBV)
Coxsackie
Echo
Parvo

52
Q

What are the viruses to be considered for a genital virus infection?

A

HSV-2

herpes simplex virus

53
Q

What are the viruses to be considered for a gastrointestinal virus infection?

A

Rota
Norwalk
Adeno 40 & 41

54
Q

What are the viruses to be considered for a congenital virus infection?

A

CMV (cytomegalo virus)
HSV (herpes simplex virus)
Ruvella

Microbiology 2: Mycology and Virology (7 decks)

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