Clinical response criteria and Performance status score

Question 1

What are Clinical response criteria

Answer 1

Are used to evaluate and copmare clinical trials with a standardized system.

WHO system

RECIST system

IRRC sytem

Question 2

List the WHO clinical response criteria

Answer 2

Complete Response
- all known lesions dissapear, 2 consecutive observations, at least 4 weeks apart.

Partial Response
- 50% or more decrease in total tumor size with no progression or new lesions

No Change
- No more than a 50% increase in total tumor size and no more than a 25% increase in any individual tumor

Progressive disease
- More than a 25% increase in any lesion or the appearance of any new lesion.

Question 3

The IRRC system

Answer 3

Immune Related Response Criteria.

Allows for a temporary increase in lesions, due to tumor flare up, which is known to occur with targeted biologic treatments.

Question 4

Performance status score

Answer 4

Uses the Karnofsky performance status score which is from 0 to 100. 0 = dead 100 = perfect.

or
the ECOG/WHO score - Eastern Cooperative Oncology Group
0 - fully active
1 - restricted in strenuous work
2 - ambulatory for more than half of the day but unable to work,
3 - limited self care, confined to bed for more than half the day.
4 - needs full care, and confined to bed.
5- dead af.