Clinical knowledge - movement and control Flashcards

1
Q

Signs of cerebellar problems

A
nystagmus
dysarthria
finger-nose ataxia
intention tremor
dysdiadokokinesis
heel-knee-shin ataxia 
gait ataxia 
falls 
signs are ipsilateral 
lesions don't produce paralysis, paresis or deficits in termination or initiation of movement
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2
Q

scoliosis

A

sideways curvature of spine
compresses lungs and abdominal organs
reduces total capacity of lungs

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3
Q

treating scoliosis

A

can be realigned with surgical rods with flexibility
spinal implant works for adults but children are still growing so treating them is difficult as repetitive surgery is required

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4
Q

what is a laminectomy

A

remove lamina to expose spinal cord or repair herniated disc
replaced by wires

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5
Q

spina bifida occulta

A

tuft of hair at point of missing spinous process

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6
Q

degeneration of intervertebral discs

A

occurs over time

causes loss of height

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7
Q

herniated intervertebral disc

A

nucleus pulposus seeps out of annulus fibrosis

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8
Q

how to test for scoliosis?

A

ask patient to bend over

one side will go lower than the other

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9
Q

caudal epidural injections

A

commonly used during birth process

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10
Q

commonly used imaging for spine

A
x-rays 
CT
MRI 
myelography 
isotype studies 
ultrasound
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11
Q

checking x-ray of cervical spine

A
A = alignment and adequacy - fractures, disruption of lines, margins between bones/ intervertebral discs 
B = bone
C = cartilage
S = soft tissues
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12
Q

when to use CT scan

A

if there is a suspicion of spinal injury

axial, sagittal or coronal can be used to look for prevertebral soft tissue swelling and cartilage or bony abnormalities

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13
Q

when to use x-ray

A

look for alignment
vertebral height
intervertebral spaces
presence of osteophytes

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14
Q

degenerative changes on x-rays

A

hypertrophy of ligaments cannot be seen but can cause more problems than osteophytes
intervertebral discs cannot be seen

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15
Q

kyphosis

A

is normal but exaggerated curvature of thoracic spine is pathological
can get kyphosis and scoliosis = kyphoscoliosis

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16
Q

spondylolistesis

A

normally affects lumbar spine
can be degenerative as ligaments become lax
can be caused by abnormality in pars interarticularis
pars defect can predispose to this
vertebra slipping backwards or forwards on 1 below

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17
Q

MRI use

A

best for visualising spinal cord and nerve roots

important for looking at cauda equina

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18
Q

disc degeneration

A

loss of height

loss of hydration

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19
Q

disc prolapse

A
loss of disc water
loss of height 
degeneration of annulus fibrosis
protrusion or extrusion 
can impinge on nerves
tension reduced in outer disc
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20
Q

myelography

A
less commonly used due to MRI 
used for those who cannot undergo MRI
injection of contrast into vertebral canal to view nerve roots and check for compression 
invasive 
more risks than MRI 
contrast injected into subdural space 
Used to diagnose disc prolapse
21
Q

ultrasound

A

can be used to see spinal canal contents in neonates

used for spina bifida occulta, cord tethering or masses - congenital abnormalities

22
Q

when can ultrasound of a baby’s spine be done?

A

up to 3 months of age as posterior elements haven’t been matured so the ultrasound beams can get through

23
Q

bone scan

A

injection of radioactive tracer
osteoblastic abnormalities uptake the radioactive tracers
looks for cancers
multiple bony metastases

24
Q

what are the most likely causes of multiple bony metastases

A

prostate or breast cancer

25
Jefferson/ burst fracture
fracture of C1
26
perched facets
misalignment of facet joints displacement anteriorly or posteriorly associated with ligament injury and sometimes bony injury
27
teardrop fracture
caused by severe flexion and compression forces associated with severe ligamentous injury bony injury usually unstable
28
epidural space abscess
non-traumatic can be infective contrast required to see on imaging
29
discitis
seen on MRI causes oedema can cause epidural abscesses
30
cauda equina syndrome
caused by compression of nerve roots below level of spinal cord diagnostic and surgical emergency
31
diagnosis of cauda equina syndrome
MRI
32
what causes cauda equina syndrome?
degenerative disease of spinal column or disc prolapses
33
risk of cauda equina syndrome
paralysis
34
what are the red flags suggesting cauda equina syndrome?
altered perineal sensation bilateral lower limb pain change in bladder habit
35
spinal metastases
from prostate primary dark on MRI can compress spinal cord - medical emergency
36
mitochondrial dysfunction
can lead to neurodegeneration because mitochondrial energy metabolism provides a line of defence against excess glutamate
37
what are the types of neurontransmitters?
amino acids monoamines peptides other
38
amino acid neurotransmitters
GABA glutamate glycine
39
monoamine neurotransmitters
catecholamines
40
peptide neurotransmitters
opioids
41
other neurotransmitters
acetylcholine
42
what are monoamines used in?
attention cognition emotion
43
opioids
involved in perception of pain
44
what is a treatment for alzheimer's disease?
galantamine
45
how does galantamine work?
Acetylcholinesterase inhibitor so prevents the breakdwon of acetylcholine so the neurotransmitter is present for longer in the synaptic cleft
46
what does nicotine do?
acts directly on all nicotinic acetylcholine receptors in the brain
47
treatments for depression
monoamine oxidase inhibitors | SSRIs
48
what do monoamine oxidase inhibitors do?
prevent breakdwon of monoamine neurotransmitters | increasing their concentration
49
how do SSRIs work?
block serotonin reuptake channels