Clinical Aspects of Breast Disease Flashcards
Name two serious side effects of Tamoxifen
Uterine (endometrial) cancer
Increased risk of thromboembolism
Raloxifene is approved for the prevention of breast cancer in which population?
Postmenopausal women only
What are the two drugs that can prevent breast cancer?
Tamoxifen and Raloxifene
What type of hyperplasia is associated with a higher risk of developing breast cancer?
Atypical hyperplasia (along with in-situ cancers)
Other than SERMs, which drugs are being used in the prevention of breast cancer (although not FDA approved)?
Aromatase inhibitors (like anastrozole)
Who should receive a screening mammograM?
Patients who are asymptomatic
Women with a palpable mass require a diagnostic mammogram
What is hte most common histology for breast cancer?
Infiltrating ductal carcinoma
Mammography is most effective at saving lives in which age group?
60-69
Acccording to the USPSTF, who shoudl be screened for breast cancer with mammograms?
Women aged 50-74, every 2 years
What is the standard of care for early breast cancer?
Lumpectomy + sentinel node biopsy + radiation
What is the most important prognostic factor for breast cancer
Lymph node involvement
What is the role of raloxifene in breast canceR?
ONLY FDA approved for breast cancer prevention and osteoporosis- not treatment
List the three aromatase inhibitors
anastrazole, letrozole and exemestane
How long are women treated with tamoxifen?
5-10 years
What are two cancers that arise as a consequence of chemotherapy?
MDS
Acute leukemia
