Class 9: Substance Use Disorders Flashcards

1
Q

Define Drugs.

A

Chemical compounds that when administered produce a physiological change in the body.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which type of drugs are most relevant in the context of substance abuse and addiction?

A

Psychoactive drugs which alter mood thought or behaviour.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

How do most psychoactive drugs exert their effects?

A

By influencing chemical signaling in the synapse.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the three different categories of psychoactive drugs?

A
  1. CNS Depressants
  2. CNS Stimulants
  3. Hallucinogens
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What do CNS Depressants do?

A

General suppression and relaxation (including suppressing mental function)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What do CNS Depressents do at low doses vs at high doses?

A

Low Dose: Calming

High Dose: Intoxication leading to sedation, coma or death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What do CNS Stimulants do?

A

Stimulate arousal giving a rapid but temporary boost of energy or clarity.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What do Hallucinogens do?

A

Alter perceptual experience; disturbing reality or cause hallucinations.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Name 3 Examples of CNS Depressants.

A
  1. Alcohol
  2. Opiates (Morphine, Heroin)
  3. Anxiolytics (Benzodiazepines, Barbiturates)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Name 4 examples of CNS Stimulants.

A
  1. Amphetamine (Meth, Speed)
  2. Cocaine
  3. Caffeine
  4. Nicotine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Name 3 Examples of Hallucinogens.

A
  1. Marijuana
  2. LSD
  3. MDMA (ecstasy)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What age group has the highest percent of alcohol drinkers?

A

Young adults (18-24) followed closely by adults (25+)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What age group has the highest percent of cannabis users?

A

Youth (15-24) followed by adults (25-44)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Is opioid use in Canada going up or down?

A

Down thanks to getting it prescribed less.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Define ‘problematic substance use’

A

When someone uses drugs or alcohol in a harmful way that has negative effects on their health and life.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Define Substance Use Disorder.

A

Uncontrolled use of a substance despite harmful consequences

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Define Addiction

A

State of uncontrolled drug use that persists in spite of negative consequences

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What are the 4 diagnosing categories of DSM-5 for Substance Use Disorders?

A
  1. Impaired Control
  2. Social Impairment
  3. Risky Use of Substance
  4. Pharmacological Criteria
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Describe the ‘Impaired Control’ Category of Diagnosing Substance Use Disorders in 4 points.

A
  1. Substance taken in larger amounts or over a larger period of time than intended
  2. Persistent desire or unsuccessful efforts to cut down or control substance use
  3. Spends a great deal of time in activities necessary to obtain/use or recover from substance
  4. Craving or strong desire/urge to use substance
20
Q

Describe the ‘Social Impairment’ Category of Diagnosing Substance Use Disorders in 3 points.

A
  1. Recurrent substance use resulting in failure to fulfill major role obligations at work/school/etc
  2. Continued substance use despite having persistent or recurrent social or interpersonal problems
  3. Important social, occupational, or recreational activities given up/reduced because of substance use
21
Q

Describe the ‘Risky Use of Substance’ Category of Diagnosing Substance Use Disorders in 2 points.

A
  1. Recurrent substance use in situations which it is physically hazardous
  2. Substance use continued despite knowledge of having a persistent or recurrent physical or psychological problem that is likely to have been caused or exacerbated by substance use
22
Q

Describe the ‘Pharmacological Criteria’ Category of Diagnosing Substance Use Disorders in 2 points.

A
  1. Tolerance, as defined by either:
    a. a need for markedly increased amounts of substance to achieve intoxication OR
    b. markedly diminished effects with continued use of the same amount of substance
  2. Withdrawal as manifested by: characteristic withdrawal syndrome OR substance is taken to avoid withdrawal symptoms
23
Q

How many critieria points do you need to be diagnosed with SUD (at each of the 3 levels) and for what timeframe

A

Mild: 2 to 3 Criteria
Moderate: 4 to 5 Criteria
Severe: 6 or more Criteria
within the last 12 months

24
Q

Define Withdrawal

A

Physical and psychological behaviours that are displayed by an individual with a SUD when the drug use ends (several hours after to possibly several days)

25
Name 11 common symptoms of withdrawal.
26
Define Reward
Stimuli that are in some way desirable or positive and can ultimately affect behaviour
27
What is the main job of the reward pathway?
Make us perform actions that help us survive and to make it easier to do them again.
28
How can certain reward pathways (for example the reward of a delicious meal) be strengthened?
Repeated activation
29
What (fundamentally) happens in the brain in the reward pathway?
1. Stimuli occurs 2. Neurons in the reward pathway will release the NT dopamine 3. Signals to motor center to make it easier to do this behaviour over and over
30
How was the reward pathway discovered?
Olds and Milner in 1954 took a rat. They put electrode in different areas of the brain and allowed the rat to activate that area themself. (intracranial self-stimulation ICCS). The rat ignored other stimuli and stimulated itself to exhaustion.
31
What is the official name of the reward pathway/circuit?
Mesocorticolimbic system
32
Where does the reward pathway start?
Ventral tegmental area (VTA)
33
What parts are involved in the Mesocorticolimbic Dopamine System?
1. Ventral tegmental area (VTA) 2. Hippocampus (Hipp) 3. Nucleus Accumbens (NAc) 4. Prefrontal Cortex (PFC)
34
What happens when dopamine is released to the NAc?
The feeling of subjective pleasure
35
What happens when dopamine is released to the Hippocampus?
Learned association between the rewarding feeling and the specific stimulus.
36
What happens when dopamine is released to the PFC?
Cognitive control necessary to seek/avoid the rewarding stimuli
37
Does every addictive drug affect the reward pathway?
Yes!
38
Do addictive drugs release more, less or around the same amount of dopamine as "natural" rewards?
Way more.
39
Why does the brain prioritize drugs over other pleasurable stimuli?
Because drugs give so much more dopamine the brain prioritizes it over the "lesser" rewards.
40
What makes cocaine very addictive?
Users are lured by the "rush" but since its effects are so short-lived, they tend to use the drug over and over again.
41
How long does it take for the cocaine rush when IV injected, Smoked, and Snorted?
Injected: 30s Smoked: 30s Snorted: 10-15 minutes
42
How long does it take for cocaine to leave the system?
2 hours.
43
How does cocaine affect the synapse?
Cocaine enters the brain and blocks the dopamine reuptake transporter resulting in dopamine accumulating in the synapse over-stimulating the mesocorticolimbic dopamine system
44
What two ways does tolerance to cocaine work in the synapse?
1. Dopamine receptors are removed from the post-synaptic membrane 2. Dopamine release from pre-synaptic terminal is reduced
45
Why can cocaine block dopamine reuptake transporter if they are supposed to be unique to their NT?
Cocaine is chemically similar to the dopamine molecule which allows it to 'fit' into the transporter just enough to get stuck.