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MCP > CItric Acid Cycle > Flashcards

CItric Acid Cycle Flashcards

1
Q

products of conversion of pyruvate to acetyl CoA?

A

2 NADH are formed

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2
Q

where does the conversion of pryuvate into acetyl COA

A

inside the mitocondria

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3
Q

WHERE DOES THE CITRIC ACID CYCLE OCCUR? WHERE DOES OXIDATION PHOSPHORYLATION OCCUR?

A

BOTH INSIDE THE MITOCONDRIA

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4
Q

eukaryotic cells without mitocondria

A

mature erhytocytes

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5
Q

3 examples of cells with high energy needs that have a lot of mitocondria as a result

A

heart for contraction

kidney for transport

liver for biosynthesis

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6
Q

In ____ cells, mitochondria account for up to 20% of the total protein.

A

liver

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7
Q

The citric acid cycle occurs in the ___ of the mitocondria

A

matrix

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8
Q

where are oxidative phosphorylation enzymes?

A

embedded in the inner membrane facing the matrix.

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9
Q

traffic between the cytoplasm and matrix space is controlled by specific transport systems, except for

A

O2 and CO, which diffuse through

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10
Q

functions of the citric acid cycle (3)

A

A. Converts a number of different fuels to a common mobile fuel (NADH).
B. Serves as the final meeting place of nearly all oxidizable substrates.
C. Provides intermediates for biosynthesis.

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11
Q

Oxidation of Pyruvate to Acetyl-CoA

first step? what is the prosthetic group?

A

Condensation and decarboxylation by pyruvate dehydrogenase (E1)

prosthetic group – TPP (thiamine b1)

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12
Q

Oxidation of Pyruvate to Acetyl-CoA

second step? what is the prosthetic group?

A

Oxidative transfer by dihydrolipoyl transacetylase

prosthetic group – lipoamide

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13
Q

Oxidation of Pyruvate to Acetyl-CoA

third step? what is the prosthetic group?

A

Transacetylation by dihydrolipoyl transacetylase

prosthetic group – lipoamide

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14
Q

Oxidation of Pyruvate to Acetyl-CoA

fourth step? what is the prosthetic group?

A

Oxidation of dihydrolipoamide by dihydrolipoyl dehydrogenase

Prosthetic group: FAD

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15
Q

The pyruvate dehydrogenase complex has multiple

A

Multiple Lipoamides/E2

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16
Q

In the pyruvate dehydrogenase complex

Dihydrolipoamide

A

______ is the site of action of arsenite poisoning

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17
Q

Importance of Lipoamide as a Swinging Arm in the pyruvate dehydrogenase complex:

A

Kinetics are fast

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18
Q

___ groups are not going on and off an ezyme, are always there

A

prosthetic

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19
Q

Acetyl CoA + oxaloacetate + H2O —> ____

by citrate synthetase

A

citrate + CoA + H+

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20
Q

important feature of this step?

A

The hydrolysis step has a ΔG°ʹ′ = -7.5 kcal/mol. Wasteful?

21
Q

Acetyl CoA + oxaloacetate + H2O → citrate + CoA + H+

enzyme?

A

Citrate synthetase

22
Q

Acetyl CoA + oxaloacetate + H2O → citrate + CoA + H+

rxn type?

A

condensation/hydrolysis

23
Q

Citrate —>

with aconitase

A

cis-aconitate + H2O

24
Q

Citrate  cis-aconitate + H2O

enzyme?

25
Q

Citrate —-> cis-aconitate + H2O

rxn type>??

A

dehydration

26
Q

cis-Aconitate + H2O —>

with aconitase

A

isocitrate

27
Q

cis-Aconitate + H2O —>  isocitrate

rxn type?

28
Q

cis-Aconitate + H2O —> isocitrate

eznyme?

29
Q

α-Ketoglutarate + NAD+ + CoA —->

α-Ketoglutarate dehydrogenase complex

A

succinyl CoA + CO2 + NADH

30
Q

α-Ketoglutarate + NAD+ + CoA –> succinyl CoA + CO2 + NADH

enzyme?

A

α-Ketoglutarate dehydrogenase complex

31
Q

α-Ketoglutarate + NAD+ + CoA –> succinyl CoA + CO2 + NADH

rxn type?

A

decrboxylation and oxidation

32
Q

Isocitrate + NAD+ —->

with Isocitrate dehydrogenase

A

α-Ketoglutarate + CO2 + NADH

33
Q

isocitrate + NAD+ ——-> α-Ketoglutarate + CO2 + NADH

enzyme?

A

Isocitrate dehydrogenase

34
Q

Isocitrate + NAD+ ——-> α-Ketoglutarate + CO2 + NADH

rxn type

A

oxidation

decarobylation

35
Q

Succinyl CoA + Pi + GDP –>

with succinyl coa synthetase

A

succinate + GTP + CoA

36
Q

Succinyl CoA + Pi + GDP —> succinate + GTP + CoA

enzyme?

A

succinyl coa synthetase

37
Q

Succinyl CoA + Pi + GDP —> succinate + GTP + CoA

rxn type?

A

substrate level phosphorylation

38
Q

Succinate + FAD (enzyme-bound) –>

A

fumarate + FADH2 (enzyme-bound)

39
Q

Succinate + FAD (enzyme-bound) —> fumarate + FADH2 (enzyme-bound)

enzyme?

A

Succinate dehydrogenase

40
Q

Succinate + FAD (enzyme-bound) —> fumarate + FADH2 (enzyme-bound)

rxn type

41
Q

Fumarate + H2O –>

42
Q

Fumarate + H2O —> malate

enzyme?

43
Q

Fumarate + H2O —> malate

reaction type

44
Q

Malate + NAD+ –>

A

oxaloacetate + NADH + H+

45
Q

Malate + NAD+ —> oxaloacetate + NADH + H+enzyme

A

malatae dehydrogenase

46
Q

Malate + NAD+ —> oxaloacetate + NADH + H+enzyme

reaction type

47
Q

Where Coa is produced?

A

with Citrate and with Succinate

48
Q

Where is NADH produced?

A

with a-ketoglutarate

with succinyl COA

with oxaloacetate

MCP (16 decks)

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