chronic myeloid leukaemia Flashcards
1
Q
define Chronic myeloid leukaemia ?
A
proliferation of primitive myeloid lineage white blood cells (myeloblasts) with proliferation in the bone marrow and blood SLOWLY PROGRESSING
2
Q
main cause of CML?
A
Philadelphia chromosome
3
Q
what are the features of Philadelphia chromosome ?
A
- chromosomal translocation between chromosomes 9 and 22
- formation of the BCR-ABL fusion gene
4
Q
epidemiology of CML?
A
- Mean age of diagnosis: 40-60 yrs
* 4 x more common in MALES
5
Q
main signs of CML?
A
• SPLENOMEGALY • Hypermetabolic Symptoms: o Weight loss o Malaise o Sweating • Bone Marrow Failure Symptoms:
6
Q
what might the bloods show?
A
o FBC • High WCC • Low Hb • Low leukocyte alkaline phosphatase • High basophils/neutrophils/eosinophils • High/normal/low platelets • High uric acid • High B12 and transcobalamin
7
Q
what might the blood film show?
A
o Immature granulocytes
8
Q
what will cytogenetics show?
A
o Show the Philadelphia chromosome
