Chp 33 Rheumatoid Arthritis Flashcards
1
Q
What are some Major Nonbiologic DMARDs? (4)
A
- immunosuppressant med; methotrexate
- antimalarial agents: hydroxychloroquine
- Anti-inflammatory med; sulfasalazine
- tetracycline antibiotic: minocycline
2
Q
What are some Major Biologic DMARDs?
A
- Etanercept
- Infliximab
- Adalimumab
- Rituximab
- Abatacept
3
Q
Pharmacological Action of DMARDs?
A
slows joint degeneration and progression of RA
4
Q
Pharmacological Action of Glucocorticoids?
A
Symptomatic relief of inflammation and pain
5
Q
Pharmacological Action of NSAIDs?
A
Provides rapid, symptomatic relief of inflammation and pain.
6
Q
What are complications of methotrexate?
A
it’s cytotoxic
- risk of infection
- hepatic fibrosis
- bone marrow suppression
- ulcerative stomatitis
- fetal death/congenital abnormalities
7
Q
What are adverse effects of hydroxychloroquine?
A
Retinal damage
8
Q
What is methotrexate contraindicated with?
A
Pt with liver failure, alcoholism, or blood dyscrasias
9
Q
Contraindications of etanercept?
A
Pt that have malignancies, active infection, hematologic disorder, or during lactation
