Cholinergic Drugs Flashcards
What are the depolarising drugs
Suxamethonium
Would be two molecules of acetylcholine
Would bind, cause and initial depolarisation and then would allow the activation
Would need to have the pseudocholinesterase molecules that would remove them from the receptor (nicotinic)
Would have a short half life but would allow enough time for the intubation
What are the non-depolarising drugs
Parocuronium
Verocuronium
Atracurium
Would be the competive antagonists
Would need to have the anticholinesterase drugs (neostigimine) that would allow the levels of ach to build up
What muscuranic receptors would be excitatory ad inhibitory
M1, M3 and M5 excitatory and use the Gq GPCRs would use the IP3
M2, M4 would be inhibitory and would use the Gi GPCRS use cAMP
What drugs would be used for incontience
The M3 receptor
Using the muscuranic antagonist so would not allow the muscle contraction when the bladder is not full
Muscarnic as smooth muscke
What is glaucoma and what drugs would be used
When there would be a build of the aqueous humour fluid in the Canal of schlemm and this would cause the build of pressure
Could also happen when there would be the folding of the iris and this would then block the canal of Schlemm
Would use the muscuranic agonists and this would allow increased Ach for more contraction
Or can have the anticholinesterases
What drugs would be used as the bronchodilators
the anticholinergic drugs that would target the M3 receptors
Would not allow ach to bind to the nicotinic receptor
Muscuranic antagonists
Iratropium
Tiotropium
Why would the bladder use the M3 receptors
The bladder would contain smooth muscle
What is myasthenia gravis
An autoimmunity disease.
The antibodies would bind to the nicotinic receptors and this would then block the Ach from being able to bind.
Would not allow any contraction
What are the side effects of the cholinergic drugs
Would be non-specific so could actually attach to any subtype of receptors
What are the functions of acetylcholine in asthma
Bronchoconstriction
Secretion of mucus blocking the airways
Why does nitric oxide not aid asthma even though it causes the brochorelaxation
Would have the effects of ach override the effects of the NO
What does the botulinum bind to
Snare proteins
Would then not allow the vesicle membrane to attach to the neuronal membrane and would not allow any ach to be released
What is LD50 and what is it for botulinum
LD50 would be the lethal dose needed to kill half the population in the sample
Would be 1.3 to 2.1ng/kg
What types of botulinum is used and what type is lethal
Type A and B used for muscle spasms and cosmetic uses
Type H would have a lethal dose of 2ng
