Adrenergic Drugs Flashcards
How would the noradrenaline be made
Tyrosine - DOPA - dopamine - noradrenaline and then adrenaline
Important enzyme would be the DOPA decarboxylase which would allow DOPA to go to dopamine
What are the types of alpha receptors
Alpha 1- would be used in the smooth muscle and would increase the PLC AND IP3 allowing more ca2+ to be released and then contraction
Alpha 2 - effector would be adenyl Cyclase but would have the decrease in the amount of cAMP released.
Would also be on the pre-synaptic membrane and would allow the negative feedback or noradrenaline
What are the types of beta receptors
The beta 1 used for the heart
Beta 2used for the lungs and brochioles
Beta 3 for the fat tissue
Also of the beta receptors would be G’s (stimulating)
What are the beta blockers used for
Hypertension
Drugs include the metoprolol and the atenolol
Would decrease the cardiac output, heart rate and the force of contraction
What would the beta agonists be used for
Would be used for asthma
Would have the beta 2 agonists like the salbutamol, would then allow the relaxation of the smooth muscle
What is shock and what is the treatment for shock
When the body wants to conserve blood and allow it to go to the certain organs so it would then decrease the delivery of blood to the peripherals (limbs)
Would have increased adrenaline so would increase the heart pumping
Would also have the beta 1 agonist, would allow the increased heart activity’s again
What is pheochromocytoma
A tumour on the medulla, causing the increased release of adrenaline
Causing hypertension
Treat by using the alpha blockers (block the alpha 1 receptor) so would decrease the heart activity
What do the beta receptors do in the heart
Increases the amount of heart activity
Increases the sinoatrial node transmission
Increased transmission to the AVN and increased contraction
What receptors would be used in the heart
Beta 1
Muscarnic 2
What are catcholamines
DOPA
DOPAMINE
NORADRENALINE
ADRENALINE
they would all be synthesised from each other
