Cholesterol Flashcards
0
Q
how is cholesterol transported?
A
transported as VLDL
1
Q
what is the rate limiting step in cholesterol biosynthesis?
A
HMG-CoA reductase
many drugs developed to attack this enzyme
2
Q
What catalyzes the esterification of cholesterol?
A
Acyl CoA cholesterol Acyl Transferase (ACAT)
3
Q
Cholesterol is precursor for steroid hormones
A
examples Glucocorticoids Mineralcorticoids Androgens Estrogens Progestins
4
Q
Gall stones
A
if CH crystalizes due to increased CH:phospholipid ratio
5
Q
Atherosclerosis
A
Foam cells form from Macrophages that have been attracted due to inflammation from constant oxidation of cholesterol in the arterial intima
6
Q
Statins inhibit
A
HMG-CoA reductase
