Chlamydiaceae Flashcards
- What type of organism are chlamydia?
- What can they do with ATP or NADP?
Obligate intracellular parasite
- Can’t synthesize ATP or reoxidize reduce NADP
What are the 2 forms of Chlamydia and what are there functions?
- Elementary body: infectious form of the organism - attaches by not expending energy or synthesizing protein.
- Reticulate body which is large, and the intracellular form of the organism. - Replicates
What fusion does chlamydia avoid to escape degradation?
- Fusion of the lysosome with the phagosome
What is serotyping in Chlamydia based on?
What are 3 clinical syndromes of most concern in the chlamydia family?
- the major outer membrane protein
- 1) “parrot fever” - chlamydophila psittaci
2) “walking pneumoniae” - C. pneumoniae
3) Trachoma, inclusion conjunctivitis, NGU, LGV are all caused by C. trachomatis
- What types of animals are C. psittaci associated with?
- What are the occupations at risk?
- birds and bird excrement - parrots, parakeets, macaws, and cockatiels
- poultry workers and veterinarians
What is the pathogenesis of C. psittaci?
- in through repiratory tract, enters via macrophages and reticuloendothelial system and has a hematogenous spread. Lung inflammation , mucous plugs, cyanosis, and anoxia
What are the symptoms of “parrot fever”?
What is diagnostic about C. psittaci?
- acute onset of fever, chills, headache, malaise, muscle aches, dry hacking cough, and bilateral interstitial pneumonia. Liver and spleen enlarged
- 4 fold increase in AB titer or indirect fluroscent antibody test.
How is C. pneumoniae acquired?
What do you see (C. pneumoniae or Mycoplasma pneumoniae) more in adults?
- respiratory droplets
- Mycoplasma more often in young people; and chlamydophila pneumoniae in adults
What are the symptoms of Walking pneumoniae?
What is the diagnostic test for C. pneumoniae?
- Pharyngitis, bronchitis, sinusitis, and pneumonia
- microimmunofluorescence
What serotypes of C. trachomatis are responsible for inclusion conjunctivitis and non-gonococcal urethritis?
- What are the seortypes that cause lymphogranuloma venerum (LGV)?
- Serotypes D-K
- L1, L2, L2a, and L3
What is the unique about the immune response of chlamydia?
- Where is Trachoma most common?
- will have neutrophils because of inflammation but won’t see bacteria because it is intracellular
- Middle East, North Africa, and india
How is trachoma (chronic keratoconjunctivits) transmitted?
What serotypes are important to know for Trachoma?
- via eye-eye, eye seeking flies as well as feces and respiratory as well in kids –> blindness
- A, B , Ba, and C
How can inflammation occur?
- How common is c. trachomatis as far as bugs that can cause neonatal conjunctivitis?
- chronic inflammation of the eyelids and scarring of the conjunctiva can cause the eyelids to turn inward and the eyelashes can abrade the cornea.
- Most common form of neonatal conjunctivits in US
What other type of eye problem is possible with C. trachomatis and what is the serotype with this problem.
- What types of eye injury is possible with it?
- Inclusion conjunctivitis - serotypes D-K, occurs in newborns and adults worldwide.
- not associated with permanent eye damage or chronicity
Non-gonococcal urethritis (NGU) is how common?
- What is the pathogenesis in women?
- Most common bacterial STD in the US, highest prevalence in teens
- infection at cervix or urethra and can spread to the fallopian tube –> possible scaring. 50% asymptomatic or discharge.
