Antibiotics Quiz

Question 1

What are the 2 possible targets for the B-lactam antibiotics?

Answer 1

• serine protease or penicillin binding proteins (PBP)

Question 2

What are the 3 methods of resistance to B-lactams?

Answer 2

1) Prevent interaction between antibiotics and target PBP (gram neg only)
2) Modification of the binding of the antibiotic to the PBP
3) Hydrolysis of he antibiotic by Beta lactamase (class A-D)

Question 3

What drugs are included in the B-lactam category?

Answer 3

• Penicillin
• Cephalosporins
• Cephamycins
• Carbapenems
• Monobactams (gram neg only)

Question 4

What B-lactam’s are resistant to more B-lactamases than Penicillin?

Answer 4

• Cephalosporins and Cephamycin

Question 5

What B-lactam has activity against virtually all groups of organism?

Answer 5

Carbapenems

Question 6

What is B-lactam works only against gram negative?

Answer 6

• Monobactams

Question 7

What is the mechanism of action of Glycopeptides (vancomysin)? What types of bacteria does it work on?

Answer 7

• inhibits cross-linkage of peptidoglycan layers

- Gram positive

Question 8

What is the mechanism of action of lipopetides (daptomycin) and the

Answer 8

Binds to the cytoplasmic membrane resulting in membrane depolarization and disruption of bacterial ionic gradients –> cell death.
Gram Positive

Question 9

What is the Bacitracin’s mechanism of action and

Answer 9

s