Chlamydia Rickettsia Flashcards
Obligate intracellular bacteria?
Chlamydia - most common STD
Rickettsia
Need ATP for cellular activity
How is the chlamydial cell wall different?
No peptidoglycan layer
No muramic acid
Two forms of chlamydia?
Elementary body - inactive but infectious, enters via endocytosis
Inclusion body - metabolically active, replicates intracellularly by fission
Two habitats of chlamydia?
Eyes
Genital tract
Most common cause of preventable blindness in the world?
Trachoma from Chlamydia
chronic keratoconjunctivitis, pull eyelid inward, lashes rub against conjunctivae
Trachoma due to what serotypes of Chlamydia?
A B and C
Africa
Blindness
Chronic infection
Oval cytoplasmic inclusions near the nuclei of conjunctival cells in trachoma?
Halberstadter Prowazek
Chlamydia serotypes responsible for STD and neonatal pneumonia?
D to K
Bacteria associated with reiter’s?
Chlamydia
Campylobacter
Can’t pee, see, climb a tree
Characteristic cough in neonatal pneumonia by chlamydia?
Paroxysmal staccato cough
Late onset 2-4 weeks
Chlamydia serotypes L1 L2 L3 cause what lesion?
LGV (Buboes)
Lymphogranuloma venereum
positive Frei test
Treatment of chlamydia STD?
Ceftriaxone for neisseria
Doxycycline (nonpregnant) or Azith (pregnant)
Also known as bird fancier’s disease?
Psittacosis
Caused by chlamydia psittaci
Parrots, parakeets
DOC for chlamydial conjunctivitis?
Erythromycin
GI upset, hepatitis
DOC for chlamydial LGV?
Doxycycline
DOC for chlamydial psittacosis?
Azithromycin
Cross reaction with proteus vulgaris strains to detect rickettsia?
Weil-Felix reaction
Vector for rickettsia in rocky mountain spotted fever?
Tick (Dermacentor)
R. rickettsii
Characteristic symptoms of RMSF?
Imagine MRS picture
Fever, conjunctival redness, headache, rash that starts in the palms, wrists then spread to trunk
Centripetal spread
Vector for rickettsia in epidemic typhus?
Body louse
R. prowazekii
Centrifugal rash that spares palms soles and face vs RMSF (centripetal)
Bacteria responsible for Q fever?
Coxiella burnetti
Unique features of Q fever vs other rickettsial infections?
No vector, no rash
Negative weil-felix
Transmitted via inhaled endospore from cowhide
Cat scratch disease?
Bartonella henselae
Cause bacterial vaginosis?
Gardnerella vaginalis
Test for bacterial vaginosis?
Whiff test
KOH - fishy odor
(+) clue cells
Cause mesenteric adenitis or pseudoappendicitis?
Yersinia enterolitica
Granuloma inguinale (Donovanosis)?
Klebsiella granulomatis
Bacteria that look like safety pins?
Yersinia pestis
Klebsiella granulomatis
Characteristic skin lesion in donovanosis?
Beefy red ulcer
Pseudobuboes
