Chlamydia infections

Question 1

What is the most common STD

Answer 1

Chlamydia trachomatis

Question 2

Many people with chlamydia have what symptoms?

Answer 2

none; they are asymptomatic

Question 3

Complications of Chlamydia include:

Answer 3

• pelvic inflammatory
• ectopic pregnancy
• infertility

Question 4

Chlamydia is an obligate what?

Answer 4

intracellular parasite

Question 5

How is chlamydia treated ?

Answer 5

antibiotics such as azithromycin or doxycycline

Question 6

What is the major virulence of Chlamydia trachomatis?

Answer 6

inflammatory response

Question 7

what are the virulence factors of Chlamydia trachomatis?

Answer 7

• outer membrane proteins
• type 3 secretion
• possible toxin that causes actin rearrangement
• iron uptake
• metabolism

Question 8

How is chamydia diagnosed?

Answer 8

• urine test or swab

- PCR based test (also called nucleic acid amplification test -NAATs)

Question 9

What is the life cycle of chlamydia?

Answer 9

1) At 0 hours:The extracellular infectious bacteria is ingested and attached to cell which reduces MOMP
2) At 9 hours:DNA reorganize; RNA synthesis and protein synthesis occurs
3) At 18 hours: Binary fission of RBs; chlamydia antigen is released from cell surface
3) At 20 hours: Fusion of inclusion; appearance of initial bodies
4) At 24 hours: DNA condensation within RB to form EBs; S-S bridging MOMP
5) At 40 hours: Infectivity increases with EB production
6) After 40 hours: Release