Candida albicans

Question 1

Candida albicans is what type of infection?

Answer 1

Fungal

Question 2

Candida albican is what type of pathogen?

Answer 2

Opportunistic pathogen

Question 3

Candida albicans are common species of what?

Answer 3

Normal flora

Question 4

Candida albicans can overgrow after what?

Answer 4

after antibiotic treatment

Question 5

Candidasis thrush is an infection where?

Answer 5

in mouth

Question 6

Invasive (severe) candida albicans can cause what type of infections?

Answer 6

Systemic blood infections

Question 7

Vaginitis is an infection where?

Answer 7

Vaginal infection

Question 8

Vaginitis is also called what?

Answer 8

Yeast infection

Question 9

Vaginitis is characterized by what?

Answer 9

• white or yellow discharge
• burning or itching
• inflamation of vagina and vulva

Question 10

The yeast form of C. albicans that cause vaginitis can grow as what?

Answer 10

fungi called pseudophyphae

Question 11

How is vaginitis diagnosed?

Answer 11

Swab samples from vaginal infection?

Question 12

what % woman experience vaginitis at least once in their lifetime ?

Answer 12

75%

Question 13

Vaginitis causes alterned normal flora of what?

Answer 13

lactobacilli

Question 14

Yeast colonizes what surfaces?

Answer 14

mucosal surfaces

Question 15

Hyphae colonize what surfaces?

Answer 15

Invades host tissues and mucosal epithelial cell layers; breaches endothelial cells.

Question 16

Yeast can dissemination (spread) where in immunocompromised host?

Answer 16

into host tissues

Question 17

Pseudohyphae hae what type of motility?

Answer 17

De facto motility

Question 18

Pseudohyphae have what type of nutritional scavenging compared to yeast?

Answer 18

Enhanced nutrient scavenging compared to yeast

Question 19

Hyphae can causes lysis to what?

Answer 19

macrophages and neutrophilis

Question 20

Hyphae have thigmotropism which is what?

Answer 20

The bending or turning of the organism in response to a touch stimulus

Question 21

hyphae have what antigen?

Answer 21

Have antigen variation

Question 22

Can candida albicans grow as a biofilm?

Answer 22

yes

Question 23

Candida albicans biofilm infections are often asociated with what?

Answer 23

medical devices

Question 24

What is the treatment for Candida albican non invasive infections?

Answer 24

fluconazole

Question 25

What is the treatment for systemic Candida albicans infection

Answer 25

amphotericin B

Question 26

Resistance mechanisms of Candida albican are similar to what? How?

Answer 26

bacteria; biofilm-specific gene expression, biofilm matrix, and efflux

Question 27

What adhesion proteins does candida albican have?

Answer 27

-AIs1p, AIsp, Hwp1p, Int1p

Question 28

What are the virulence factors of candida albican?

Answer 28

1) Adhesion proteins
2) Morphogenesis into invasive filaments
3) degradative enzymes
4) Phenotypic switching

Question 29

What are the degradation enzymes of candida albican?

Answer 29

• various proteinases,
• aspartyl protease
• phospholipases

Question 30

Phenotypical switching plays a role in what?

Answer 30

• altering yeast’s adherence properties
• antigen expression
• tissue affinity

Question 31

Phenotypical switching helps in what?

Answer 31

adaption