Candida albicans Flashcards

1
Q

Candida albicans is what type of infection?

A

Fungal

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2
Q

Candida albican is what type of pathogen?

A

Opportunistic pathogen

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3
Q

Candida albicans are common species of what?

A

Normal flora

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4
Q

Candida albicans can overgrow after what?

A

after antibiotic treatment

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5
Q

Candidasis thrush is an infection where?

A

in mouth

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6
Q

Invasive (severe) candida albicans can cause what type of infections?

A

Systemic blood infections

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7
Q

Vaginitis is an infection where?

A

Vaginal infection

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8
Q

Vaginitis is also called what?

A

Yeast infection

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9
Q

Vaginitis is characterized by what?

A
  • white or yellow discharge
  • burning or itching
  • inflamation of vagina and vulva
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10
Q

The yeast form of C. albicans that cause vaginitis can grow as what?

A

fungi called pseudophyphae

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11
Q

How is vaginitis diagnosed?

A

Swab samples from vaginal infection?

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12
Q

what % woman experience vaginitis at least once in their lifetime ?

A

75%

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13
Q

Vaginitis causes alterned normal flora of what?

A

lactobacilli

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14
Q

Yeast colonizes what surfaces?

A

mucosal surfaces

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15
Q

Hyphae colonize what surfaces?

A

Invades host tissues and mucosal epithelial cell layers; breaches endothelial cells.

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16
Q

Yeast can dissemination (spread) where in immunocompromised host?

A

into host tissues

17
Q

Pseudohyphae hae what type of motility?

A

De facto motility

18
Q

Pseudohyphae have what type of nutritional scavenging compared to yeast?

A

Enhanced nutrient scavenging compared to yeast

19
Q

Hyphae can causes lysis to what?

A

macrophages and neutrophilis

20
Q

Hyphae have thigmotropism which is what?

A

The bending or turning of the organism in response to a touch stimulus

21
Q

hyphae have what antigen?

A

Have antigen variation

22
Q

Can candida albicans grow as a biofilm?

23
Q

Candida albicans biofilm infections are often asociated with what?

A

medical devices

24
Q

What is the treatment for Candida albican non invasive infections?

A

fluconazole

25
What is the treatment for systemic Candida albicans infection
amphotericin B
26
Resistance mechanisms of Candida albican are similar to what? How?
bacteria; biofilm-specific gene expression, biofilm matrix, and efflux
27
What adhesion proteins does candida albican have?
-AIs1p, AIsp, Hwp1p, Int1p
28
What are the virulence factors of candida albican?
1) Adhesion proteins 2) Morphogenesis into invasive filaments 3) degradative enzymes 4) Phenotypic switching
29
What are the degradation enzymes of candida albican?
- various proteinases, - aspartyl protease - phospholipases
30
Phenotypical switching plays a role in what?
- altering yeast's adherence properties - antigen expression - tissue affinity
31
Phenotypical switching helps in what?
adaption