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RUSVM VZ > CHemo drugs > Flashcards

CHemo drugs Flashcards

1
Q

What phase of the cell cycle do plant alkaloids work on?

A

Mitosis

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2
Q

Which phase do Antimetabolites work on in the cell cycle?

A

S- phase

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3
Q 
Cytosine arabinoside
6-fluorouracil
6-mercaptopurine
Methotrexate
Are examples of what kind of drug?
A

Antimetabolites

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4
Q

Vincristine and vinblastine are examples of what type of drug?

A

Plant alkaloids

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5
Q

Doxorubicin and Epirubicin are examples of what type of drug?

A

Anti-tumor antibiotics

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6
Q

What do we use Chemotherapy for in Solid tumor treatments?

A
  • -Residual Primary turmor removal

- -Delay growth of subclinical metastases

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7
Q

What do you use to adjust the dosage of Carboplatin?

A

GFR helps define Carboplatin dosage

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8
Q

What do you use to determine Vincristine dosage?

A

Neutrophil nadir

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9
Q

What kind of Neutrophil Nadir improves outcome?

A

1000-1500 cells/microLiter

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10
Q

What is the MDR1 gene?

A

A p-glycoprotein that codes for drug resistance.

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11
Q

How do you minimise aersols?

A

Luer locks
Venting devices
closed systems

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12
Q

What’s the period of Risk for Mitoxantrone/Cisplatin?

A

the longest; 8 days

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13
Q

What is the period of risk for Chlorambucil?

A

The shortest; Two Days.

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14
Q

What side effect does Cisplatin cause?

A

Renal damage

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15
Q

What side effect does Doxorubicin have?

A

Cardiomyopathy

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16
Q

What side effect does Cyclophosphamidine have?

A

Cystitis

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17
Q

What side effect does L-asparginase have?

A

Hypersensitivity

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18
Q

What side effect does Vincristine have?

A

Neuropathy

19
Q

Which two drugs are associated with exacerbating the common GI signs seen?

A

L-asparaginase(Pancreatits)

Cisplatin (Central effect)

20
Q

What’s a common appetite stimulant?

A

Cyproheptadine

21
Q

What’s a common Anti-emetic?

A

Maropitant/Metoclopramide

22
Q

When does myelosuppression commonly show?

A

5-10 days after chemotherapy

23
Q

What is one ‘identifier’ of neutrophil recovery seen after myelosuppression?

A

Monocytosis predict imminent neutrophil recovery

24
Q

How myelosuppressive is L-asparaginase?

A

Mildly

25
Q

How Myelosuppressive is doxorubicin?

A

Highly

26
Q

How myelosuppressive is Vincristine?

A

Mildly

27
Q

What can you use to reduce the likelihood of gastrointestinal antibiotics?

A

TMS for 14 days post- doxorubicin reduces the likelihood of gastrointestinal antibiotics.

28
Q

When is Lomustine used for?

A

Lymphoma rescue

CCNU

29
Q

what is Melphalan used for?

A

Multiple Myeloma

30
Q

What is chlorambucil used for?

A

GI lymphoma

31
Q

How long do Alkylating drugs have an effect?

A

Short acting

32
Q

What is a good way to prevent alkylating drug side effects?

A

Mesna
Salt in the diet
Walk frequently

33
Q

What happens when Cyclophosphamide causes sterile hemorrhagic cystitis?

A
  • -Culture to distinguish from a UTI
  • -NSAID
  • -Never use cyclophosphamide again
34
Q

What is Mitoxantrone used for?

A

lymphoma, soft tissue, carcinomas/sarcomas

35
Q

What is important to monitor with antitumor antibiotic side-effects?

A

Fractional shortening
Cardiac troponins
(helps to administer antihistamines priors)

36
Q

What are Cisplatin and carboplatin examples of?

A

Platinums

37
Q

What are the side effects of platinum?

A

Fatal PULMONARY OEDEMA in feline -cisplatin

Myelosuppression-mild

38
Q

What are examples of Mitotic inhibitors?

A

Vincristine-TVT

Vinblastine- Mastcell tumor

39
Q

What is a partial response?

A

Decrease in tumor volume of >50%

40
Q

What is a complete response?

A

No detectable tumor

41
Q

What is a ‘stable disease’ of tumors?

A

Decrease 10%

42
Q

What is a progressive disease?

A

> 10% growth of the mass

43
Q

What are some Phase non-specific drugs?

A

Alkylating agents
Anti-tumor
Antibitoics
(misc; L-asparginase, Cisplatin)

RUSVM VZ (8 decks)

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