CHemo drugs

Question 1

What phase of the cell cycle do plant alkaloids work on?

Answer 1

Mitosis

Question 2

Which phase do Antimetabolites work on in the cell cycle?

Answer 2

S- phase

Question 3

Cytosine arabinoside
6-fluorouracil
6-mercaptopurine
Methotrexate
Are examples of what kind of drug?

Answer 3

Antimetabolites

Question 4

Vincristine and vinblastine are examples of what type of drug?

Answer 4

Plant alkaloids

Question 5

Doxorubicin and Epirubicin are examples of what type of drug?

Answer 5

Anti-tumor antibiotics

Question 6

What do we use Chemotherapy for in Solid tumor treatments?

Answer 6

• -Residual Primary turmor removal

- -Delay growth of subclinical metastases

Question 7

What do you use to adjust the dosage of Carboplatin?

Answer 7

GFR helps define Carboplatin dosage

Question 8

What do you use to determine Vincristine dosage?

Answer 8

Neutrophil nadir

Question 9

What kind of Neutrophil Nadir improves outcome?

Answer 9

1000-1500 cells/microLiter

Question 10

What is the MDR1 gene?

Answer 10

A p-glycoprotein that codes for drug resistance.

Question 11

How do you minimise aersols?

Answer 11

Luer locks
Venting devices
closed systems

Question 12

What’s the period of Risk for Mitoxantrone/Cisplatin?

Answer 12

the longest; 8 days

Question 13

What is the period of risk for Chlorambucil?

Answer 13

The shortest; Two Days.

Question 14

What side effect does Cisplatin cause?

Answer 14

Renal damage

Question 15

What side effect does Doxorubicin have?

Answer 15

Cardiomyopathy

Question 16

What side effect does Cyclophosphamidine have?

Answer 16

Cystitis

Question 17

What side effect does L-asparginase have?

Answer 17

Hypersensitivity

Question 18

What side effect does Vincristine have?

Answer 18

Neuropathy

Question 19

Which two drugs are associated with exacerbating the common GI signs seen?

Answer 19

L-asparaginase(Pancreatits)

Cisplatin (Central effect)

Question 20

What’s a common appetite stimulant?

Answer 20

Cyproheptadine

Question 21

What’s a common Anti-emetic?

Answer 21

Maropitant/Metoclopramide

Question 22

When does myelosuppression commonly show?

Answer 22

5-10 days after chemotherapy

Question 23

What is one ‘identifier’ of neutrophil recovery seen after myelosuppression?

Answer 23

Monocytosis predict imminent neutrophil recovery

Question 24

How myelosuppressive is L-asparaginase?

Answer 24

Mildly

Question 25

How Myelosuppressive is doxorubicin?

Answer 25

Highly

Question 26

How myelosuppressive is Vincristine?

Answer 26

Mildly

Question 27

What can you use to reduce the likelihood of gastrointestinal antibiotics?

Answer 27

TMS for 14 days post- doxorubicin reduces the likelihood of gastrointestinal antibiotics.

Question 28

When is Lomustine used for?

Answer 28

Lymphoma rescue | CCNU

Question 29

what is Melphalan used for?

Answer 29

Multiple Myeloma

Question 30

What is chlorambucil used for?

Answer 30

GI lymphoma

Question 31

How long do Alkylating drugs have an effect?

Answer 31

Short acting

Question 32

What is a good way to prevent alkylating drug side effects?

Answer 32

Mesna Salt in the diet Walk frequently

Question 33

What happens when Cyclophosphamide causes sterile hemorrhagic cystitis?

Answer 33

- -Culture to distinguish from a UTI - -NSAID - -Never use cyclophosphamide again

Question 34

What is Mitoxantrone used for?

Answer 34

lymphoma, soft tissue, carcinomas/sarcomas

Question 35

What is important to monitor with antitumor antibiotic side-effects?

Answer 35

Fractional shortening Cardiac troponins (helps to administer antihistamines priors)

Question 36

What are Cisplatin and carboplatin examples of?

Answer 36

Platinums

Question 37

What are the side effects of platinum?

Answer 37

Fatal PULMONARY OEDEMA in feline -cisplatin Myelosuppression-mild

Question 38

What are examples of Mitotic inhibitors?

Answer 38

Vincristine-TVT | Vinblastine- Mastcell tumor

Question 39

What is a partial response?

Answer 39

Decrease in tumor volume of >50%

Question 40

What is a complete response?

Answer 40

No detectable tumor

Question 41

What is a 'stable disease' of tumors?

Answer 41

Decrease 10%

Question 42

What is a progressive disease?

Answer 42

>10% growth of the mass

Question 43

What are some Phase non-specific drugs?

Answer 43

Alkylating agents Anti-tumor Antibitoics (misc; L-asparginase, Cisplatin)