Chemistry of amino acids Flashcards
1
Q
Strong acids
A
ionise completely
2
Q
Weak acids
A
do not ionise completely
3
Q
Strong bases
A
Ionise completely
4
Q
Weak bases
A
do not ionise completely
5
Q
Important biological buffers
A
Weak acids and bases
6
Q
Henderson-Hasselbalch Equation
A
pH=pKa + log10 [conjugate base]
[acid]
7
Q
pKa of 𝛼-carboxyl group and 𝛼-amino group
A
𝛼-carboxyl pKa= 1.82-2.38 depending on amino acid
𝛼-amino pKa=8.80-10.96 depending on amino acid
8
Q
Side chains
A
pHpKa side chain will be deprotonated ∴neutral
Asp/Glu: –COOH ó –COO- + H+,
Lys: -NH3+ ó -NH2 + H+,
Cys: -SH ó -S- + H+
