Chem- Krebs/etc/cori Flashcards
What is the fuel for the krebs cycle
Acetyle CoA (made from the 2 pyruvate in glycolosis)
How does pyruvate change to acetyl CoA
pyruvate dehydrogenase
rate limiting step of krebs
isocitrate dehyrogenase
end prducts of Krebs
3 NADH
1FADH
1GTP
2C02
what do each NADH and FADH produce
NADH- 3 atps
FADH- 2 atps
Where can pros enter the krebs
SOFA
-succinayl CoA
Oxaloacetate
Fumerate
A ketogluterate
what are the 2 points fat can enter the krebs
A ketogluterate
succinyle Coa
How does nadh made in the cytosol pass into the mitochondria for the ETC
malate aspartate
glycerol 3 phosphate shuttles
How does the malate aspartate shuttle work
cytosolic oxaloacetate reduced by malate by NADH
malate crosses mito
reoxidizes to oxaloaceptate
(has to conervte to asparatete to cross back out)
How does the gyleroc 3 phos shuttle work
DHAP is reduced to G3P and enters the mito and reacts with FAD to make FADH
where does NADH enter the ETC
Complex I
Where does FADH enter the ETC
Complex II (succinate dehydrogenase complex w coenzyme q)
What happens at complex IV
copper is used to transfer electrons
What happens at complex V
ATP synthase
-Oxygen is electron acceptor and oxygen is consumed and ate generated
What inhibits cytochrome C
Cyanide and Carbon monoxide
What is the Cori cycle
the metabolic pathway that occurs in the liver and is used to prevent lactic acid build u (converts it back to pyretic acid then to glucose thru glucneogenesis)
How much ATP does the cori cycle use
Uses 4 molecules of ATP
What is the goals of the pentose phosphate shuttle (3)
fatty acid synthesis
Detoxification
protection from free rads
What is the fuel for the pentose phosphate path and limiting enzyme
Cytosol
G6P
Glucose 6 phosphate dehydrogenase
End result of pentose phosphate
2 NADH
Ribose (for nucleotide synthesis)
what is the initial step in glycogenesis
Glycogen synthase (also rate limiting)
What is the rate limiting of glycogenolysis
Glycogen phosphorylase A/B
How is glycogenolysis regulated
Stimed by glucagon and epinephrin
Inhibited by insulin
