Chapters 12-4,5,6,7: Subtypes of classical Hodgkin lymphoma

Question 1

morphology of NSCHL characterized by

Answer 1

collagen bands surrounding at least 1 nodule, and lacunar type cells

Question 2

Mediastinal involvement occurs in __% of NSCHL

Answer 2

80%

Question 3

what is the “syncytial variant” of NSCHL?

Answer 3

aggregates of lacunar cells resembling granulomas

Question 4

Prognosis of NSCHL

Answer 4

better than other CHLs

Question 5

MIxed cellularity CHL is seen more frequently in

Answer 5

HIV+ and developing countries

Question 6

Histiocytes in MC-CHL may be particularly epithelioid it

Answer 6

EBV assd

Question 7

% of MC-CHL that are LMP1/EBER+

Answer 7

75%

Question 8

Defining features of Lymphocyte rich CHL

Answer 8

absense of PMNs and eos

Question 9

Age range for lymph rich CHL

Answer 9

significantly higher than other CHL

Question 10

Growth patterns of lymph rich CHL

Answer 10

nodular (common)

diffuse (rare)

Question 11

Nodules in lymph rich CHL represent expanded___

Answer 11

Mantle zones (IgM+D+)

Question 12

Granulocytes may be present in what areas in lymph rich CHL

Answer 12

interfollicular zones

Question 13

lymph depleated CHL has predilection for what areas

Answer 13

retroperitoneal LN, solid organs, Bone marrow

Question 14

Unifying feature of lymph depleated CHL

Answer 14

predominance of HRS cells compared to non-neoplastic inflammatory cells