Chapter 12-3: Classical Hodgkin Lymphoma, Introduction

Question 1

Classical HL is __% of HL

Answer 1

95%

Question 2

ages of CHL patients

Answer 2

15-35yrs

late in life

Question 3

subtypes of CHL with strongest EBV association

Answer 3

mixed cellularity

lymphocyte depleated

Question 4

75% of CHL occurs in what location

Answer 4

cervical LN

Question 5

subtype of CHL with most mediastinal involvment

Answer 5

nodular sclerosis

Question 6

% of BM involvement in CHL

Answer 6

5%

Question 7

Adominal and splenic involvement seen most often with which subtype

Answer 7

mixed cellularity

Question 8

CHL in thymus is associated with

Answer 8

cystic degeneration and epithelial hyperplasia

Question 9

Lacunar cells are characteristic of

Answer 9

Nodular sclerosis CHL

Question 10

% of HRS cells that are + for CD15

Answer 10

75-85%

Question 11

if + in HRS cells, CD20

Answer 11

has varied intensity and is only in a minority of neoplastic cells

Question 12

PAX5 in HRS cells

Answer 12

weaker intensity than non-neoplastic Bcells

Question 13

IRF/MUM1 in CHL

Answer 13

consistently +

is a plasma cell specific transcription factor

Question 14

OCT2, BOB1, and PU.1 in CHL

Answer 14

absent in >90%

Question 15

most difficult differential diagnosis with CHL

Answer 15

large B cell lymphoma withanaplastic morphology and CD30+

Question 16

Clonal IG gene rearragements in __% of CHL

Answer 16

98%

Question 17

Subtype with highest frequency of EBV+

Answer 17

mixed cellularity (75%)

Question 18

Subtype with lowest frequency of EBV+

Answer 18

nodular sclerosis (10-40%)

Question 19

Translocation that is sometimes seen in CHL

Answer 19

t(14;18) if arising from a follicular lymphoma