Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

WHO Hematopathology > Chapter 12-2: Nodular lymphocyte predominant Hodgkin lymphoma > Flashcards

Chapter 12-2: Nodular lymphocyte predominant Hodgkin lymphoma Flashcards

1
Q

Histologic pattern of NLPHL is ___ or ___

A

nodular or

nodular and diffuse

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

name of neoplastic cells in NLPHL

A

LP cells (popcorn cells)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

composition of nodules in NLPHL

A

meshwork fo follicular dendritic cells, non-neoplatic lymphocytes and histiocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

classic pt for NLPHL

A

male 30-50yrs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

NLPHL cannot be distinguised form __ by immunophenotype

A

THRLBCL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what benign LN condition may proceed, follow, or be seen concurrent with NLPHL

A

progressive transformation of germinal centers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

staining with ___ shows expanded network of FDCs in NLPHL

A

CD21

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

LP cell immunophenotype

A

+ CD20, CD79a, CD75, BCL6, CD45

- CD15, CD30

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

J-chain in NLPHL

A

positive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

OCT2, BOB1, and AID (activation induced daminase) in NLPHL

A

positive in NLPHL and negative in CHL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

CD30+ cells in NLPHL are likely

A

reactive immunoblasts

rarely LP cells can have weak 30+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Cells ringing LP cells are

A

CD3, CD57+ T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

markers expressed by T cells in NLPHL

A

cMAF, PD1, BCL6, IRF4/MUM1, CD134

germinal center T cell markers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

staining pattern for EMA in LP cells

A

membrane and Golgi (ring and dot)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

prominence of extra-nodular LP cells is associated with:

A

development of a diffuse pattern

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

NLPHL that has recurred with a diffuse pattern is called

A

THRLBCL-like NLPHL

17
Q

EBV in NLPHL

A

negative in LP cells (may be + in surrounding non-neoplastic cells)

18
Q

somatic hypermutations in __% of NLPHL

A

80% (PAX5, PIM1, RhoH/TTF, MYC)

19
Q

prognosis of NLPHL

A

very good (80% at 10yr) if stage 1 or 2

20
Q

bone marrow involvment in NLPHL

A

rare. if it is present, think about THRLBCL

WHO Hematopathology (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions