Chapter 9-3: T-lymphoblastic leukemia/lymphoma

Question 1

T-LBL comprises ___% of lymphoblastic lymphomas

Answer 1

85-90%

Question 2

T-ALL/LBL is most commonly seen in

Answer 2

adolescent males

Question 3

of mitotic figures is said to be ___ in T-ALL than B-ALL

Answer 3

higher

Question 4

T-LBL may rarely have nodular pattern in LN, mimicking

Answer 4

Follicular lymphoma

Question 5

T-LBL with eosinophils in tissue may be assd with

Answer 5

eosinophilia and myeloid hyperplasia
8p11 abnormality (FGFR1 gene)

Question 6

most specific markers of precursor T-lymphoblasts

Answer 6

TdT, CD99, CD34, CD1a

Question 7

non-T-lineage markers that can be seen on T-ALL

Answer 7

CD79a, CD10, CD13, CD33, CD117

Question 8

CD117+ T-ALL has been assd with what genetic abnormality

Answer 8

activating FLT3 mutations

Question 9

Pro-T phenotype

Answer 9

cCD3+, CD7+, CD2-, CD1a-, CD34+/-

Question 10

Pre-T phenotype

Answer 10

cCD3+, CD7+, CD2+, CD1a-, CD34+/-

Question 11

cortical T phenotype

Answer 11

cCD3+, CD7+, CD2+, CD1a+, CD34-

Question 12

medullary T phenotype

Answer 12

cCD3+, CD7+, CD2+. CD1a-, CD34-, sCD3+

Question 13

_____ is double negative for CD4 and CD8

Answer 13

Pro-T and Pre-T

Question 14

_____ is double positive for CD4 and CD8

Answer 14

cortical T

Question 15

T-ALL/LBL has IGH gene rearragment in __%

Answer 15

20%

Question 16

Most comon recurrent genetic abnormalties in T-ALL

Answer 16

alpha and delta TCR at 14q11
beta locus at 7q35
gamma locus at 7p14

Question 17

2 most common partners for TCR rearragments in T-ALL

Answer 17

HOX11 (TLX1) 10q24

HOX11L2 (TLX3) 5q35

Question 18

MOst important deletion in T-ALL

Answer 18

del(9p) CDKN2A (a tumor suppressor)

Question 19

50% of T-ALL show activating mutation of ___

Answer 19

NOTCH gene

Question 20

Downstream target of NOTCH1

Answer 20

MYC