Chapter 9-2: B-ALL with recurrent genetic abnormalities

Question 0

PH positive ALL more common in:

Answer 0

Adults (25% of the adult, 2–4% of children)

Question 1

Chromosome abnormality in B-ALL with worst prognosis

Answer 1

t(9;22) BCR-ABL1

Question 2

Immunophenotype of t(9;22) B – ALL

Answer 2

+ 10, 19, TdT
More frequent myeloid (13, 33)
CD25

Question 3

CD25 expression in B-ALL higly assd with what genetic abnormality

Answer 3

t(9;22)

Question 4

t(9;22) may rarely have _______ phenotype

Answer 4

T precursor

Question 5

BCR-ABL1 in B-ALL usually is ____ kd

Answer 5

p190

50% of adult is p210

Question 6

Chromosome abnormality most frequently seen in B-ALL in <1yr olds

Answer 6

MLL (KMT2A) rearrangements

Question 7

MLL rearrangements found by what type of FISH probe

Answer 7

Breakapart

Question 8

Clinical features of MLL rearranged ALL

Answer 8

WBC >100

CNS positive

Question 9

In some cases of leukemia with MLL rearrangement, it amy be possible to recognize distinct lymphoblastic and ____ populations. This should be considered _____.

Answer 9

Monoblastic

B/myeloid leukemia

Question 10

Typical immunophenotype of t(4;11) or MLL rearranged ALL

Answer 10

19+, 10-, 15+, NG2+

Question 11

abnormality seen in B-ALL with phenotype of 19+, 15+, NG2+, 10-

Answer 11

t(4;11), MLL

Question 12

most common translocation partner in MLL rearranged B-ALL

Answer 12

AF4 on 4q21

Question 13

2 other translocation partners with MLL

Answer 13

ENL on 19p13

AF9 on 9p22

Question 14

MLL-ENL fusions/ t(9;19) also common in

Answer 14

T-ALL

Question 15

MLL-AF9 t(9;11) mosre common in ___ than B-ALL

Answer 15

myeloid leukemia

Question 16

MLL leukemias frequently associated with what other abnormality

Answer 16

FLT3 overexpression

Question 17

B-ALL with very favorable prognosis

Answer 17

t(12;21) ETV6-RUNX1

hyperdiploidy

Question 18

B-ALL with t(12;21) is ___% of B-ALL in children, ___ in adults, ___ in infants

Answer 18

25% in children
rare in adults
rare in infants

Question 19

immunophenotype of t(12;21) B-ALL

Answer 19

myeloid antigens (13, 33) common
absent 9, 20, 66c

Question 20

chromosome trisomies with best prognosis

Answer 20

4, 10, 17 together

Question 21

definitition of hypodiploid B-ALL

Answer 21

greater than 50 chromosomes

Question 22

hyperdiploid B-ALL common in ___, rare in ____, not seen in ___

Answer 22

common in children
rare in adults
not seen in infants

Question 23

most commonly increased chromosomes in hyperdiploid B-ALL

Answer 23

21, X, 14, 4

Question 24

pitfall for hyperdiploid B-ALL

Answer 24

hypodiploid B-ALL with endoreduplication

Question 25

definition of hypodiploid ALL

Answer 25

less than 46 chromosomes

Question 26

hypodiploid ALL seen in ____

Answer 26

children adn adults

Question 27

near-haploid ALL seen in ___

Answer 27

children only

Question 28

structural abnormalities are uncommon in ___

Answer 28

near-haploid ALL

Question 29

if discrepancy between karyotype and FISH in regards to chomosome number, suspect___

Answer 29

hypodiploidy

Question 30

B-ALL with eosinophilia

Answer 30

t(5;14) IL3-IGH

Question 31

Prognosis of B-ALL with t(5;14)

Answer 31

used to be bad prognosis, but with new chemo, not so bad anymore

Question 32

B-ALL with cytoplasmic mu heavy chain positive pre-Bcell phenotype

Answer 32

t(1;19) TCF3-PBX1

Question 33

Immunophenotype of t(1;19) B-ALL

Answer 33

positive cytoplasmic mu heavy chain
strong CD9+
CD34- or limited