Chapter 9-1: B-lymphoblastic leukemia/lymphoma, NOS

Question 1

ALL in the US is _____ precursor B-cell phenotype

Answer 1

80-85%

Question 2

B-LBL is ___% of lymphoblastic lymphomas

Answer 2

10%

Question 3

B-LBL frequently presents where in body?

Answer 3

Head and Neck

Question 4

“Hand-mirror” cells

Answer 4

seen in 10% of B-ALL, cytoplastmic pseudopod

Question 5

Lymphoblasts staining patterns with MPO, SUdan black, PAS

Answer 5

MPO = negative
Sudan black = granules are light grey
PAS = coarsly granular +

Question 6

NSE patterns in lymphoblasts

Answer 6

punctate or Golgi staining

variable inhibition with sodium fluoride

Question 7

PAX5 may be + in tissue sections of AML with

Answer 7

t(8;21)

Question 8

pro-B ALL phenotype

Answer 8

CD19+, cCD79a+, cCD22+, TdT +

Question 9

common B-ALL phenotype

Answer 9

CD10+

Question 10

pre-B ALL phenotype

Answer 10

cytoplasmic mu chains +

Question 11

clonal TCR rearrangements may be seen in __% of B-ALL

Answer 11

up to 70%

Question 12

common additional genetic abnormalities in B-ALL

Answer 12

del(6q), del(6p), del(12p)

Question 13

2 genetic lesions with poor prognosis in B-ALL which are not part of recurrent genetic abnormalities group

Answer 13

t(17;19) E2A-HLF

iAMP21

Question 14

clincial adverse prognostic indicators in B-ALL

Answer 14

10yrs
high WBC
slow response to chemo
residual dz
CNS+