Chapter 9.7

Question 1

What are the two major functions of the pentose pathway

Answer 1

1) Serves as a source of ribose 5-phosphate

2) Leads to production of NADPH

Question 2

What is the rate limiting enzyme of the pentose pathway

Answer 2

-it is glucose-6-phosphate dehydrogenase(G6PD)

Question 3

What is G6PD induced by? What is it inhibited by

Answer 3

• it is induced by insulin
• > abundance of sugar entering the cell induces fuel storage pathways like the pentose pathway

-it is inhibited by NADPH but activated by NADP+

Question 4

What are the functions of NADPH

Answer 4

1) biosynthesis
- >mainly of fatty acids and cholesterol

2)assisting in cellular bleach production in certain white blood cells

3) Maintenance of a supply of reduce glutathione to protect against reactive oxygen species
- >glutathione is a reducing agent that can help reverse radical formation before the damage is done

4)Protect cells from free radical oxidative damage caused by peroxides