Chapter 9 Flashcards
Committed lymphocyte progenitors originate in the:
bone marrow.
Hematopoietic stem cells cultured in the presence of which receptor differentiate into T cells rather than B cells?
Notch-ligand
Which of the following molecules would double-negative T cells fail to express?
CD4
Signaling through the pre-TCR occurs as a result of:
successful assembly of the pre-TCR
At what stage of T cell development is the pre-TCR expressed?
DN
Signaling through the pre-TCR results in:
All of the above
Which of the following represents the earliest stage in T-cell development?
DN
T cells selected on a b haplotype thymus would be able to respond to antigen presenting on which of the following haplotype antigen presenting cells?
B and C
Injecting a TCR transgenic mouse with the peptide that it recognizes would result in an increase in which process?
Negative selection
MHCa mice that are irradiated and reconstituted with MHCa × b bone marrow would accept grafts from which of the following donors?
A, B, and C
In negative selection, cells that receive _____________ signal through their antigen receptors die.
a strong
What happens to autoreactive cells that escape the thymus?
All of the above
How do self-antigens that are specific to tissues away from the thymus (like insulin or keratin for example) get in the thymus so that developing T cells that react to them can be deleted?
A transcription factor, AIRE is expressed in thymic medullary epithelial cells, which allows these cells to express proteins normally found in other tissues.
Superantigens differ from regular peptide antigens because they:
All of the above
What is currently the best explanation for what determines whether a T cell develops into a CD8+ T cell or a CD4+ T cell?
CD4 or CD8 expression is determined by the strength and duration of the TCR/MHC interaction.
