Chapter 10

Question 1

B lymphocytes are made in the:

Answer 1

bone marrow.

Question 2

How long does B cell maturation from an HSC to a mature B cell take?

Answer 2

1 to 2 weeks

Question 3

Which cell type is found in both B- and T-cell lineages?

Answer 3

Common lymphoid progenitors

Question 4

This type of cell will leave the bone marrow and complete maturation in the spleen.

Answer 4

immature B cell

Question 5

All of the following are true regarding B-cell development EXCEPT:

Answer 5

B cells, like T cells, are MHC class restricted.

Question 6

Hematopoiesis produces:

Answer 6

erythorid, lymphoid, and myeloid lineage cells.

Question 7

Hematopoiesis begins at around day 7 after fertilization in mice. What is the site of precursor cells at this stage of fetal development?

Answer 7

Yolk sac

Question 8

At what site can fetal HSCs be found by day 8 in the mouse model?

Answer 8

AGM (aorta-gonad-mesonephros)

Question 9

At what site(s) can mature HSCs be found by day 11 in the mouse model?

Answer 9

All of the above

Question 10

What type of cell will predominately be produced by hematopoiesis in the fetal liver of mice?

Answer 10

Erythroid lineage cells

Question 11

VDJ recombination occurs during which phase of a B cell’s development?

Answer 11

Pro-B cell

Question 12

What are two functions of bone marrow stromal cells with respect to B-cell development?

Answer 12

Cytokine expression and traps developing B cells in a specific location

Question 13

Individuals of retirement age or older show lower antibody mediate immune responses due to all of the following reasons EXCEPT:

Answer 13

smaller thymus.

Question 14

What type of immunoglobulin gene rearrangement occurs during B-cell progenitor development?

Answer 14

Both heavy- and light-chain rearrangement

Question 15

The common lymphoid progenitor cell gives rise to all of the following cell lines EXCEPT:

Answer 15

megakaryocytes.

Question 16

Which of the following statements regarding HSCs is/are TRUE?

Answer 16

Statements II and IV only

Question 17

Where can early lymphoid progenitor cells (ELPs) be found in humans?

Answer 17

Bone marrow

Question 18

At what stage of development does a B cell begin to express a pre-B-cell receptor?

Answer 18

Late pre-B cell

Question 19

At what stage of development does a B cell undergo D-JH rearrangement?

Answer 19

Early pro-B cell

Question 20

At what stage of development does a B cell begin to display an IgM receptor?

Answer 20

Immature B cell

Question 21

B-cell development has one checkpoint to determine if V-DJ rearrangement has produced a successful VH-DJH combination that does not recognize self. If no successful combination is produced, then the B cell will undergo apoptosis. At what point of B-cell development does this checkpoint occur?

Answer 21

Late pro B cell

Question 22

How does allelic exclusion prevent multiple heavy-chain rearrangements from occurring in pre-B cells?

Answer 22

RAG1 and RAG2 are down-regulated, and TdT activity is lost so that no additional heavy-chain rearrangements may take place.

Question 23

Mature naïve B cells express high levels of ____ on their cell surfaces.

Answer 23

IgD

Question 24

Mature B-2 or follicular B cells are most commonly found in the:

Answer 24

secondary lymphoid organs.

Question 25

Mature B-1 cells show ______ diversity in their V-region.

Answer 25

low (restricted)

Question 26

Marginal-zone B cells express:

Answer 26

Both B and C

Question 27

Which type of mature B cell is MOST likely to respond to a protein antigen?

Answer 27

B-2 B cells and MZ B cells

Question 28

What is the initial location of B-cell and T-cell development?

Answer 28

Bone marrow for both B cell and T cell

Question 29

Which cell type undergoes negative selection of ectopic expressing self-antigen cells in primary lymphoid organs?

Answer 29

T cells

Question 30

V-J rearrangement occurs in:

Answer 30

both B cells and T cells.