Chapter 2 Flashcards
All blood cells in an adult human can trace their ancestry to which compartment within the body?
Bone marrow
A pluripotent stem cell can do which of the following?
Differentiate into a finite number of different cell types
Which of the following is the pluripotent stem cell that gives rise to all blood cells?
HSC
From which of the following stem cells are NK cells derived?
CLP
From which of the following stem cells are DCs derived?
Both A and B
From which of the following stem cells are platelets derived?
CEP
From which of the following stem cells are eosinophils derived?
CMP
From which of the following stem cells are helper T cells (TH) derived?
CLP
From which of the following stem cells are monocytes derived?
CMP
From which of the following stem cells are RBCs derived?
CEP
What level of gene expression is regulated by such factors as Notch1, GATA-2 and Bmi-1?
Transcription
Which lineage of immune cells constitutes the first line of defense against an infection?
Myeloid
Which of the following is NOT descended from the common lymphoid progenitor?
Eosinophils
Which of the following granulocytes contains histamine within its granules?
Basophils
Which of the following is NOT true about monocytes?
They can give rise to platelets.
Which of the following cell types is responsible for the secretion of immunoglobulins?
Plasma cell
Which of the following cell types is responsible for regulating responses against intracellular pathogens?
TH1
Which of the following cell types is responsible for activating B cells in germinal centers?
TFH
Which of the following cell types is responsible for regulating responses against predominantly extracellular pathogens?
TH2
Which of the following cell types secretes IL-17 and may play a role in anti-fungal responses?
TH17
Which of the following effector T lymphocyte populations is produced via the activation of a naïve T cell through antigen presented in MHC Class I?
CTL
Which of the following types of effector T lymphocytes is capable of inhibiting an immune response to an antigen recognized with its T-cell receptor (TCR)?
Treg
Which of the following descendants of the CLP act in the innate immune response?
NK cells
Which of the following is NOT considered primary lymphoid tissue?
Choices A and C are not primary lymphoid tissue.
In mammals, T-cell development occurs in the ____________, while B-cell development occurs predominantly in the ______________.
thymus; bone marrow
As thymocytes develop, they are classified on the basis of the state of their T-cell receptors and which of the following?
The presence of coreceptor proteins CD4 and CD8 on their surface
Upon entering the thymus, thymocytes are classified as double __________ with regard to coreceptor; before exiting as single-positive, naïve T cells, they pass through a period in which they are double ________.
negative; positive
Contraction of which of the following types of muscles is responsible for propulsion of lymph through the lymphatic system?
Both B and C
Naïve lymphocytes enter secondary lymphoid tissues via which of the following structures
HEVs
Which of the following does NOT appear to utilize the FRCC system as its primary means for trafficking through the lymph node?
B cells
