Chapter 2

Question 1

All blood cells in an adult human can trace their ancestry to which compartment within the body?

Answer 1

Bone marrow

Question 2

A pluripotent stem cell can do which of the following?

Answer 2

Differentiate into a finite number of different cell types

Question 3

Which of the following is the pluripotent stem cell that gives rise to all blood cells?

Answer 3

HSC

Question 4

From which of the following stem cells are NK cells derived?

Answer 4

CLP

Question 5

From which of the following stem cells are DCs derived?

Answer 5

Both A and B

Question 6

From which of the following stem cells are platelets derived?

Answer 6

CEP

Question 7

From which of the following stem cells are eosinophils derived?

Answer 7

CMP

Question 8

From which of the following stem cells are helper T cells (TH) derived?

Answer 8

CLP

Question 9

From which of the following stem cells are monocytes derived?

Answer 9

CMP

Question 10

From which of the following stem cells are RBCs derived?

Answer 10

CEP

Question 11

What level of gene expression is regulated by such factors as Notch1, GATA-2 and Bmi-1?

Answer 11

Transcription

Question 12

Which lineage of immune cells constitutes the first line of defense against an infection?

Answer 12

Myeloid

Question 13

Which of the following is NOT descended from the common lymphoid progenitor?

Answer 13

Eosinophils

Question 14

Which of the following granulocytes contains histamine within its granules?

Answer 14

Basophils

Question 15

Which of the following is NOT true about monocytes?

Answer 15

They can give rise to platelets.

Question 16

Which of the following cell types is responsible for the secretion of immunoglobulins?

Answer 16

Plasma cell

Question 17

Which of the following cell types is responsible for regulating responses against intracellular pathogens?

Answer 17

TH1

Question 18

Which of the following cell types is responsible for activating B cells in germinal centers?

Answer 18

TFH

Question 19

Which of the following cell types is responsible for regulating responses against predominantly extracellular pathogens?

Answer 19

TH2

Question 20

Which of the following cell types secretes IL-17 and may play a role in anti-fungal responses?

Answer 20

TH17

Question 21

Which of the following effector T lymphocyte populations is produced via the activation of a naïve T cell through antigen presented in MHC Class I?

Answer 21

CTL

Question 22

Which of the following types of effector T lymphocytes is capable of inhibiting an immune response to an antigen recognized with its T-cell receptor (TCR)?

Answer 22

Treg

Question 23

Which of the following descendants of the CLP act in the innate immune response?

Answer 23

NK cells

Question 24

Which of the following is NOT considered primary lymphoid tissue?

Answer 24

Choices A and C are not primary lymphoid tissue.

Question 25

In mammals, T-cell development occurs in the ____________, while B-cell development occurs predominantly in the ______________.

Answer 25

thymus; bone marrow

Question 26

As thymocytes develop, they are classified on the basis of the state of their T-cell receptors and which of the following?

Answer 26

The presence of coreceptor proteins CD4 and CD8 on their surface

Question 27

Upon entering the thymus, thymocytes are classified as double __________ with regard to coreceptor; before exiting as single-positive, naïve T cells, they pass through a period in which they are double ________.

Answer 27

negative; positive

Question 28

Contraction of which of the following types of muscles is responsible for propulsion of lymph through the lymphatic system?

Answer 28

Both B and C

Question 29

Naïve lymphocytes enter secondary lymphoid tissues via which of the following structures

Answer 29

HEVs

Question 30

Which of the following does NOT appear to utilize the FRCC system as its primary means for trafficking through the lymph node?

Answer 30

B cells