Chapter 8 - Naloxone Hydrochloride

Question 1

Presentation?

Answer 1

400 micrograms per 1 ml ampuole.

Question 2

Indications?

Answer 2

Opioid overdose producing respiratory, cardiovascular and CNS depression.

Overdose of an opioid analgesic (codeine).

Overdose of an opioid compound analgesic (co-codamol).

Unconscious patient where opioid overdose is a possibility.

Question 3

Actions?

Answer 3

Antagonism of the effects of opioid drugs.

Question 4

Contraindications?

Answer 4

Neonates born to opioid addicted mothers.

Question 5

Side effects?

Answer 5

Can produce violent withdrawal symptoms from the opioid drug.

Question 6

Administration route?

Answer 6

Intramuscular - vary site of injection for repeated doses.

Appropriate sites are gluteus maximus, vastus lateralis, gluteus medius and deltoid.

Question 7

Initial dose?

Answer 7

400 micrograms.

Question 8

Repeat dose?

Answer 8

400 micrograms.

Question 9

Dose interval?

Answer 9

3 minutes.

Question 10

Volume?

Answer 10

1ml

Question 11

Max dose?

Answer 11

4,400 micrograms (11 doses).