Chapter 8

Question 1

DEFINE

Depressant

Answer 1

A drug that diminishes physiological activity and cortical arousal

Question 2

EXPLAIN

How do most depressants work?

Answer 2

By increasing GABA neurotransmission

Question 3

DEFINE

Barbiturates

Answer 3

any of a class of sedative and sleep-inducing drugs derived from barbituric acid.

Question 4

WHO, WHY, WHERE?

What drug company initally began the production and marketing of Barbiturates?

Answer 4

Bayer

Question 5

LIST

What are the sites of action of barbiturates?

Answer 5

• cerebral cortex
• Amygdala
• Thalamus
• Medulla

Question 6

EXPLAIN

How can barbiturates result in death?

Answer 6

Suppression of medulla, resulting in respiratory depression

Question 7

DEFINE

Shrinking Theraputic Index

Answer 7

When the theraputic index becomes smaller with chronic use, increasing the risks of overdosing on the same dosage

Question 8

LIST

What are 3 commons benzodiazepines?

Answer 8

1. Librium
2. Valium
3. Xanax

Question 9

LIST

What are 2 types of benzodiazepine sites?

Answer 9

1. BZI (High affinity)
2. BZII (Low Affinity)

Question 10

DEFINE

Endozepines

Answer 10

Naturally occuring benzodiazepines from within the body