Chapter 7 Pt 4 Flashcards
what is dextromethorphan
opioid common in COUGH SYRUP
what is a common cause of morbidity from street heroin use
infection secondary to needle sharing
what is seen in opioid intoxication
nausea vomiting sedation decreased pain perception decreased GI motility pupil CONSTRICTION constipation slurred speech respiratory depression (can be fatal)
opioids effects on what mediated addictive and rewarding properties
dopaminergic systems
what are the most commonly used opioids
prescription (not heroin)
MAOI and what opioid can cause serotonin syndrome (hyperthermia, confusion, muscular rigidity)
MEPERIDINE
what opioid is exception to opioids causing miosis
MEPERIDINE (demerol)
Demerol Dilated pupils
what is the classic triad of opioid overdose
Rebels Admire Morphine
Respiratory depression
Altered mental status
Miosis
what is treatment of choice for opioid overdose
naloxone
what is seen in opioid withdrawal
ANXIETY INSOMNIA ANOREXIA PILOERECTION RHINORRHEA N/V/F DILATED pupils YAWNIGN abdominal cramps dysphoria insomnia lacrimation weakness sweating arthralgia/myalgia
how does naltrexone work
competitive opioid antagonist
precipitates withdrawal if used w.in 7 days of heroin
eating large amounts of what can cause a positive UDS for opioids
poppy bengals or muffins
what is methadone
long-acting ovoid receptor agonist
administered 1x/day
significantly REDUCES MORBIDITY and MORTALITY in opioid dependent persons
causes QTc PROLONGATION
what is “GOLD-STANDARD” treatment in pregnant opioid dependent women
methadone
what is buprenorphine
partial opioid receptor agonist
sublingual prep that is SAFER THAN METHADONE