Chapter 7 pt 3 Flashcards

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1
Q

how do amphetamines work

A

block reuptake and facilitate the release of dopamine and norepinephrine from never endings, causing stimulant effect

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2
Q

heavy use of amphetamines can induce what

A

amphetamine induced psychosis- a state that may MIMIC SCHIZOPHRENIA

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3
Q

what are the symptoms of amphetamine abuse

A
euphoria
dilated pupils
increased libido
tachycardia
perspiration
grinding teeth
chest pain
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4
Q

how does MDMA work

A

release dopamine, norepinephrine, and serotonin from nerve endings

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5
Q

amphetamine and MDMA overdose can lead to what

A

hyperthermia
dehydration
rhabdomyolysis
renal failure

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6
Q

how doe sone treat MDMA and amphetamine intoxication

A

rehydrate
correct electrolytes
treat hyperthermia

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7
Q

what are the signs of ketamine intoxication

A

tachycardia
tachypnea
hallucinations
amnesia

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8
Q

what are the symptoms of PCP intoxication

A
RED DANES
Rage
Erythema
Dilated pupils
Delusions
Amnesia
Nystagmus
Excitation
Skin dryness
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9
Q

rotatory nystagmus is strongly suggestive of what

A

PCP intoxication

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10
Q

amphetamine withdrawal can lead to prolonged what

A

depression

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11
Q

what is PCP

A

dissociative hallucinogenic that antagonizes NMDA glutamate receptors and activates dopaminergic neurons

stimulating or depressing effect depending on the dose taken

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12
Q

overdose of PCP or ketamine can cause what

A

seizures
delirium
coma
even death

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13
Q

how does one treat PCP or ketamine intox

A

monitor vitals, temp, electrolytes
minimize sensory input
benzos (lorazempam) to treat agitation, anxiety, muscle spasms, and seizure
antipsychotics (haloperidol) to control severe agitation or psychotic symptoms

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14
Q

there is no withdrawal from PCP or ketamine but what can one experience after taking it and what

A

FLASH BACKS- recurrence of intoxication symptoms from release of drug from body LIPID STORES

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15
Q

tactile and visual hallucinations are seen in what drug intoxication

A

cocaine and PCP

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16
Q

what agents are in the sedative-hypnotics category

A
benzos
barbs
zolpidem
zaleplon
gamma-hydroxybutyrate (GHB)
meprobamate
17
Q

what drug more often than others results in violence

A

PCP

18
Q

what is gamma hydroxybutyrate (GHB)

A
dose-dependent CNS depressant that produces:
confusion
dizziness
drowsiness
memory loss
resp distress
coma
DATE-RAPE DRUG
19
Q

how do benzos work

A

Benzos are my Frenzos

increase frequency of chloride channel opening thus potentiating GABA

20
Q

what are barbiturates used for and how do they work

A

epilepsy and anesthesia

increase duration of chloride channel opening thus potentiates GABA
high doses direct GABA agonist

21
Q

what does intoxication off sedative-hypnotics

A
drowsiness
confusion
hypotension
slurred speech
incoordination
ataxia
mood lability
impaired judgement
nystagmus
respiratory depression
coma or death if overdose
22
Q

long term sedative use can lead to what

A

dependence and may cause depressive symptoms

23
Q

of withdrawal from all kinds of drugs, which has the highest mortality rate

A

barbiturates (withdrawal can be deadly)

24
Q

what is flumazenil

A

very short-acting BDZ antagonist used for treating BDZ overdose
use with caution b/c may PRECIPITATE SEIZURES

25
Q

how does one treat barbiturate overdose

A

alkalinize urine with sodium bicarbonate to promote renal excretion

26
Q

how is sedative-hypnotic OD treated

A

maintain ABCs
monitor vitals
activated charcoal and gastric lavage to prevent further GI absorption (if drug ingested in prior 4-6 hours)

27
Q

what can happen from sedative-hypnotic withdrawal

A

death homie

28
Q

in general what kinds of drugs cause life threatening withdrawal

A

sedating drugs (alcohol, barbs, benzos)

29
Q

how is sedative-hypnotic withdrawal treated

A

benzo taper