Chapter 7 - Cartilage Flashcards
What is the progression of a cartildge cell starting as MSC?
MSC -> Condragenic cell -> Condroblast -> trapped in ECM -> Condrocyte
Is cartilage vascular? What does this mean for the ECM?
Cartilage is avascular which means nutrients and waste must move through the ECM. Which means the ECM must be very hydrated and move slowly
What are the 2 functions the hydrated ECM serve?
- Allows for the diffusion of nutrients etc
- Increases pliabilty
What are the two main compotnent of cartilage? At what percentages?
- Condrocytes
- ECM (95%)
What are condrocytes trapped in?
Lacunae
What in the ECM allows it to draw in water?
The ECM has high GAG and proteoglycans which are anionic, draw in cations, which draw in water
What are the three types of cartilage?
- Hyaline
- Elastic
- Fibrocartilage
Which cartilage(s) are surrounded by a perichondrium?
- Hyaline
- Elastic
What makes up the ECM of hyaline cartiledge?
- Type II collagen
- GAGs and proteoglycans
- Multi-adhesive protiens
What is the perichondrium?
It is the site of growth, it houses chondragenic cells
Where is hyaline cartilage found?
- Fetal skeletal tissue
- Rib cage
- Nasal vavity, larynx, trachea
- Articular Cartilage
What type of cartilage is articular cartilage? What is it’s function? Where is it located?
Hyaline Cartilage
Found on the joints of long and short bones
Allows for smooth, fluid movement
What is the ECM made of in Elastic cartilage?
Same as hyaline (II collagen, GAGs, proteoglycans,multiadhesive protiens)
PLUS elastic fibers
What do the elastic fibers in elastic cartilage ECM do?
They increase stretching capacity
Where is elastic cartilage located? (3)
- External ear
- Epiglottis
- Auditory tube
What does fibrocartilage lack that the other two have?
A perichondrium
What makes up the ECM of fibrocartalidge?
Same material as hyaline cartidage (Type II collogen, GAGs, progetoglycans, multiadhesive protiens)
PLUS type I collogne
What function does the type I collagen fibers in fibrocartilage serve?
It increased the strength and allwos for increased impact
Where is fibrocartalege found? (3)
Invertebral discs
Meniscis (knee)
Pubic symphysis
What causes asteoarthritus?
Cartilage wears away which leads to bone on bone interactions -> inflammation and damage
What are the 4 functiosn of hyaline cartilage?
- Resist compresion
- Provide cushion and low-friction surface
- Structural support
- Foundation for development of fetal skeleton
What are the 3 compotents that make up hyaline cartilage?
- Matrix / ECM
- Perichondrium
- Chondrocytes in lacunae
What are the two main types of collagen found in hyaline cartilage? What are their functions?
- Type II - strength
- Type IX - anchor down components of matrix to create the fluid network
What is an aggrecan? What purpose does it surve in hyaline cartilage matrix?
A primary protetoglycan with chondroitin and keratan sulfates
Sulfates carry a neg charge –> –> water
What do mutli-adhesive glycoprotiens do?
Act as glue that hold the components of the matrix together
What are the two types of multi-adhesive glycoprotiens that are found in hyaline cartilage matrix? What do they do?
- Anchorin CII - allows to attach to fibers in matrix
- Fibronectin - anchors chondrocytes to matrix
What are the compotents of hyaline cartilage? (5)
- Water (60-80%)
- Collagen (15%)
- Aggrecans (9%)
- Multi-adhesive protiens (5%)
- Condrocytes (3-5%)
What are the two layers of the perichondrium?
- Outer Fibrous layer: fibroblasts, make type I collagen
- Inner chondogenic layer: condrogenic cells that differentiate into condroblasts and then into condrocytes
What is the perichondrium?
Dense irregular collagenous CT membrane that surround cartilage on the ourside
What two cartilages don’t have a perichondrium?
Articular Cartilage
Fibrocartilage
When chondrocytes group together what are they called?
Isogenous groups
What do chondrocytes do?
Synthesize and maintian the ECM
What gives chondrocytes thier vaculoe apperence or emptiness?
High glycogen and lipid stores