Chapter 7 book notes Flashcards
what causes obesity?
-many interrelated causes
Two major contributing and interacting factors that cause obesity:
1)genetics
2)environment
Prader-Willi syndrome
-genetic disorder characterized by excessive appetite, massive obesity, short stature, and often intellectual disability.
How many sites in the human genome is associated with obesity & fat distribution?
-more than 300 sites
For someone with at least one obese parent, the chance of becoming obese is estimated to fall between…
30-70%
An individuals genetic inheritance may make obesity likely, it will not necessarily develop unless gives a push by
-environmental factors that encourage energy consumption and discourage energy expenditure.
Lipoprotein lipase
-enzyme mounted on the surface of fat cells
-hydrolyzes triglycerides in the blood into fatty acids and glycerol for absorption into the cells.
LPL promotes..
-fat storage in fat cells and muscle cells
-people with high LPL activity are especially efficient at storing fat
leptin:
-a hormone produced by fat cells under the direction of the obesity gene
- it is in proportion to the amount of fat stored.
- It decreases appetite and increases energy expenditure.
A gain in body fatness stimulates the production of…? And what stimulates the release of leptin?
-leptin
-hypothalamus
Fat loss produces the opposite effect—
-suppression of leptin production
-increased appetite
-decreased energy expenditure
Because leptin is a protein, it would be destroyed during digestion if given orally, so it must be given through a?
-injection
Obese people do not have leptin deficiency, they produce plenty of leptin, but
-they fail to respond to it.
-condition known as “leptin resistance”
Ghrelin
-a hormone produced primarily by the stomach
cells.
-It signals the hypothalamus of the brain to stimulate appetite by increasing smell sensitivity, stimulating appetite, and promoting efficient energy storage.
Ghrelin powerfully triggers the desire to..
-eat
Blood levels of ghrelin typically rise..
-before a meal and fall after a meal
High ghrelin levels correlate with..
-lower body weight
-when body is in negative energy balance (low-kcal diet)
Low levels of ghrelin correlate with..
-higher body weight
-positive energy balance
Ghrelin and sleep duration:
-a lack of sleep increases levels of ghrelin
-helps explain the associations between inadequate sleep, higher energy intakes, and weight gain.
The amount of fat in adipose tissue reflects both..
-the number and size of fat cells
The # of fat cells increases most rapidly during..
-the growing years of late childhood and early puberty.
Obesity causes fat cells to get bigger, but after they reach their maximum size..
-more cells can develop to store more fat.
With fat loss, the size of cells shrink, but
-their number cannot
-because of this people with extra fat cells may tend to regain lost weight rapdily
When is prevention of obesity most critical?
-during the growing years if childhood and adolescence when the # of fat cells increases to the most profound extent.
Excess fat first fills..
if fat is still abundant, the excess if then deposited..
-bodys natural storage site (adipose tissue)
-in organs such as the heart and liver
set-point theory:
-the theory that the body tends to maintain a certain
weight by means of its own internal controls (physiologically related)
The theory suggests that the body somehow chooses
-a preferred weight and defends that weight by regulating eating behaviors and hormonal actions.
Microbiota may affect..
-many body systems (brain, adipose tissue, and muscles) that can alter the bodys use and storage of energy.
When the mix of bacterial species falls out of balance, potentially…
-harmful bacteria proliferate
-producing substances that increase inflammation and are associated with obesity, diabetes, etc.
Determining whether certain bacteria might be the cause or consequence of weight change is difficult, because…
-colonies quickly grow or diminish with changes in diet.
obesogenic environment:
-all the factors surrounding a person that promote weight gain
-such as an increased food intake—especially of unhealthy choices—and decreased physical activity.
FDA requires chain restaurants with 20 or more locations, including fast food, to provide..
-kcalorie information on menus and menu boards for each standard menu item.
hunger:
-the physiological need to eat
-programmed into people by their heredity
Appetite
-the psychological desire to eat;
-a learned motivation
-can lead people to ignore hunger or respond to it
satiation:
-the feeling of satisfaction and fullness that occurs during a meal and halts eating.
-determines how much food is consumed during a meal.