Chapter 5-PowerPoint Lectures Flashcards
Difference between integral and peripheral proteins?
integral proteins go through the bilayer membrane while peripheral proteins do not
What do biological membranes consist of?
lipids and proteins
What is glycerol?
3-carbon polyalcohol
What is the structure of cholesterol?
3 benzene rings, 1 pentane ring, hydrophobic tail attached to the pentane ring, and a hydroxyl group on the benzene ring end (hydrophilic)
What is the function of cholesterol?
helps in membrane fluidity (only in certain concentrations)
Why is it called fluid mosaic model?
phospholipids and proteins are freely moving around
Which move around at a great rate phospholipids or proteins?
phospholipids
What does “Mosaic” refer to?
membrane proteins—not uniform all around the surface
What are the purpose of membrane protien?
transport, recognition, receptors, cell adhesion
What helps keep membranes fluid at low temperatures?
unsaturated fatty acids
How does cholesterol help with membrane fluidty?
prevents hydrocarbon tails from stiffening
What does cholesterol do at higher temperatures?
stabilizes membranes and decreases fluidity
How do eukaryotic organisms adapt to colder temps?
changing membrane lipids—hibernation
Double bonds (increases unsat. fatty acids to improve fluidity) and cholesterol increase
Do membrane proteins move around in the bilayer?
Frye and Edidin’s experiment, they found it did b/c the chimera cell had the human and mouse cell proteins mixed together
What do antibodies do?
proteins that specifically recognizes the protein of interest
What is chimera?
mixing of two cells (ex. mixing a mouse and human cell)
What can integral membrane proteins also be called?
transmembrane proteins
Which (nonpolar/polar) move through the membrane easily? (selective permeability)
nonpolar hydrophobic molecules
Which (nonpolar/polar) move through the membrane harder? (selective permeability)
polar hydrophilic molecules
need a membrane protein to get across
Do charges atoms and molecules blocked by membrane?
yes they are blocked by the hydrophobic core
What are types of passive transport?
simple diffusion, facilitated diffusion, osmosis
Where do passive transport get its energy from?
concentration gradient
What are the forms of active transport?
primary and secondary
Where does primary active transport get its energy from?
ATP
Where does secondary active transport get its energy from?
other energy forms other than ATP
What does it mean when active transport moves against the gradient?
moving from low to high concentration—need energy!
What is another name for secondary active transport?
coupled transports
What does simple diffusion transport?
non polar inorganic gases such O2,N2, CO2 and organic molecules
What is transported with facilitated diffusion?
polar and charged molecules that need transport proteins such as water, amino acids , sugars, and ions
What is the difference between facilitated and simple diffusion?
facilitated diffusion need a transport protein to go across the membrane
What are channel proteins?
integral membrane proteins that allow water and ions to pass
What do auqaporins transport?
water—type of channel protein
Are ion channels open usually?
No they are gated
What states are gated channels?
open, closed, or intermediate
What proteins are involved in facilitated diffusion?
channel and carrier proteins
What does it mean when the carrier protein can become saturated?
too many solute molecules to transport or not enough carrier proteins
What does it mean when the carrier protein can become saturated?
too many solute molecules to transport or not enough carrier proteins
What does change in conformation mean?
change of shape of the protein
What does simple diffusion depend on?
molecular size and lipid solubility
Which are permeable to the cell membrane?
gases, small uncharged polar molecules
What are not permeable to the cell membrane?
large uncharged polar molecules, ions, charged polar molecules