Chapter 5- Neurohormones Flashcards

Exam 1

1
Q

What are hormones and what do they affect?

A
  • Hormones are chemical signals secreted by specialized cells (ex. glands)
  • They travel widely (often through bloodstream) to act on specific receptors
  • Hormones affect our reproductive behavior, feeding + drinking, stress + emotion
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2
Q

Endocrine vs exocrine glands

A
  • Endocrine glands release hormones within the body
  • Exocrine glands use ducts to secrete fluid/hormones such as tears and sweat outside the body
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3
Q

What type of glands does the NS have?

A

The nervous system contains endocrine glands and is the target of endocrine glands

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4
Q

How do hormones communicate?

A

-Endocrine
-Paracrine
-Autocrine

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5
Q

How does endocrine communication work?

A

A hormone is rleased into the bloodstream to act on target cells/organs

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6
Q

How does paracrine communication work?

A

A released chemical diffuses to nearby target cells with no synapse/action potential involved
- gets secreted and then floats around in the near vicinity

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7
Q

How does autocrine communication work?

A

A released chemical acts on the cell that released it (secretion and target cell are the same)
-important for cell regulation

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8
Q

Very long distance hormonal communication

A
  • pheromone communication: hormones between individuals of the same species (dogs smelling where a teritory was marked)… some attractive/repellant
  • Allomone communication: hormonal communication across species (ex. bee and flower)
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9
Q

General principles of hormone action

A
  • Hormones are released widely (effects determined by where receptors are located, each organ may respond differently; organ target affects hormone effect)
  • hormonal signals can be slow, seconds to hours
  • Hormonal effects can be gradual and last up to weeks
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10
Q

How do hormones affect behavior?

A
  • Hormones modulate behavior, but don’t usually initiate/terminate it
  • Behavior can alter hormone release (traveling to a different time zone affects melatonin production)
  • Hormone levels cycle over day, month, lifetime
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11
Q

Similarities between neurotransmitters and hormones

A
  • Both systems synthesize, store, and release chemical signals
  • Both use specific receptors, often with intracellular biochemical pathways
  • Both systems can affect behavior (and behavior will affect these systems)
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12
Q

Differences between hormones and neurotransmitters

A
  • NT travels to precise destinations bc neurons are connected via synapses
  • Hormones spread throughout the body, but only act on cells with correct receptor
  • Hormonal messages are slower
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13
Q

T/F: Some chemicals can be both hormones and neurotransmitters?

A

True

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14
Q

How can neurons initiate endocrine signals?

A
  • Neuroendocrine (aka neurosecretory) cells are neurons that release hormones into the blood in response to action potential
  • The hormone crosses the blood-brain barrier, flowing until it affects the target cell (which can be located in the brain or somewhere else in the body)

neuroendocrine cells are found in the hypothalamus

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15
Q

What three types of chemicals serve as hormones?

A
  • Peptide hormones
  • Amine hormones
  • Steroid hormones
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16
Q

What are peptide hormones?

A
  • string of amino acids

aka protein hormone

ex. ACTH (Adrenocorticotropic hormone)

17
Q

What are amine hormones?

A

modified amino acids- ends will be slightly different (ex. have an extra COOH group)

aka monomine hormones

Ex. Thyroxine (tetraiodothyronine) and norepinephrine

18
Q

What are steroid hormones?

A
  • 4 rings of carbon atoms (made from cholesterol)

Ex. stradiol

19
Q

What type of receptors do hormones bind to?

A
  • metabotropic
  • or nuclear
20
Q

What do peptide and amine hormones bind to?

A
  • Metabotropic (work through second messenger system, coupled to g-proteins)
  • Structurally: have 7 transmembrane proteins joined together that transverse the phsopholipid bilayer
  • Binding site outside of the cell is bound to the g-protein inside the cell
  • Can take seconds to minutes to take effect
  • ex. cAMP, IP3, DAG
21
Q

What do steroid and neurosteroids bind to?

A
  • nuclear receptors (found inside the cell often on the nucleus… hormone diffuses through membrane first)
  • Bind to transcription factor (genetic info)
  • Take a very long time to take effect
22
Q

What are negative feedback loops and how do they work? (regulation/inhibition)

A
  • Detect, evaluate, and regulate hormone levels and biological effects
  • hormone is steadily released
  • only if enough hormone was released, does the negative feedback signal get sent
  • multiple levels of hormone release, multiple levels of negative feedback
23
Q

Hypothalamus and Pituitary Gland

A
  • Hypothalamus: neuroendocrine cells secrete “releasing hormones”
  • Pituitary gland: secretes “tropic hormones”
  • Anterior pituitary:
  • Posterior pituitary: Oxyocin and Vasopressin
  • Endocrine glands (adrenal gland, thyroid, etc) secretes hormones targeting specific cells/organs
24
Q

Posterior Pituitary Gland

A
  • neurons of the hypothalamus release peptide hormones into bloodstream of the posterior pituitary gland
  • Oxytocin: social bond formation between parents/offspring and sexual partners… reproductive physiology, uterine contraction, and lactation
  • Vasopressin: thirst/water regulation, increases blood pressure and inhibits urine formation
  • This hormone release is action potential dependent
25
Q

Anterior Pituitary Gland

A
  • Hypothalamic neurons synthesize releasing hormones into median eminence blood vessels called the hypophyseal portal system (web of vessels)
  • Releasing hormones are carried to the antierior pituitary
  • Anterior pituitary releases tropic hormones into blood stream
  • Tropic hormones spread throughout the body
26
Q

HPA Axis

A
  • HPA= hypothalamus- Pituitary- Adrenal
  • The adrenal cortex/adrenal gland secretes steroids, including glucocorticoids
  • Cortisol is a glucocorticoid hormone that prepares the body to deal with stress
27
Q

What does cortisol do that prepares the body to deal with stress?

A
  • Increases blood glucose
  • Promotes metabolism
  • Suppresses inflammation
28
Q

The nervous system is an endocrine gland t/f

A

T

29
Q

The NS is the target of endocrine glands T/F

A

T