Chapter 43: Muscles, Bones, and Body Movements Flashcards
Which types of muscle are under voluntary control?
skeletal
Which types of muscle are under involuntary control?
smooth and cardiac
What connects bone to bone?
ligaments
What connects muscle to bone?
tendons
Which nervous system controls the skeletal muscle?
somatic nervous system
Are skeletal muscles multinucleated?
yes
What is a fasicle?
bundle of muscle fibers
What are myofibrils? composition?
make up muscle fibers
made of thin and thick filaments
What gives skeletal muscle a striated appearance?
alternating pattern of thin and thick filaments
What are A bands?
Dark bands at both ends of stacked thick filaments where thin filaments overlap
Where ACTION takes place
What is the H zone?
Lighter middle region of an A band, which contains only thick filaments
What is the M line?
A disc of proteins in the center of the H zone, which holds the stack of thick filaments together
MIDDLE of the sarcomere
What are I bands?
Light bands consisting of the parts of the thin filaments not in the A band
connects 2 sarcomeres
What is the Z line?
A thin disc in the center of each I band to which the thin filaments are anchored
end, edge, boundary
What is a sarcomere?
the basic unit of contraction in a myofibril
What are thick filaments?
are parallel bundles of myosin molecules, each consisting of two subunits that form a head connected to a long double-helix tail – the head bends toward the adjacent thin filament to form a crossbridge
heads away from middle and towards the Z-line
What are thin filaments?
contain two linear chains of actin molecules twisted into a double helix
tropomyosin and troponin are found here
What happened to the sarcomere when a muscle is fully contracted?
-Z lines get closer together, doesn’t change shape just
moves
-actin and myosin overlap
-actin doesn’t change shape or move
What does interdigitated mean?
(of two or more things) interlock like the fingers of two clasped hands.
What are the steps in forming a cross-bridge/muscle contraction?
1) myosin head binds to ATP, detaches from actin
2) Myosin head catalyzes (breaks down) ATP forming ADP which cocks the myosin head back
3) Myosin head hinds to actin forming a cross-bridge
4) ADP and Pi are released which created a power stroke that causes thin filament to slide which shorten the sarcomere
What is rigor mortis?
Can tell time of death by presence of ATP, For a while after death ATP is still produced which allows for cross-bridge formation still.
Within a few hours after death, Ca2+ diffuses into the cytoplasm of muscle cells and initiates the crossbridge cycle, producing rigor mortis
What is the sarcoplasmic reticulum?
complex system of vesicles modified from smooth ER that encircle the sacromeres
Segments of sarcoplasmic reticulum wrap around each A and I band, separated from T tubules by small gaps
What are T tubules?
At the junction of an A band and I band, the plasma membrane folds to form a T (transverse) tubule
on top of Z line, hollow tube that plunges down into the tissue
What neurotransmitter is responsible for neural muscular control? what does this cause?
acetylcholine, causes the release o f Na+ ions that depolarize the membrane which then release Ca2+ ions from voltage gated channels
What role does Ca2+ play in skeletal muscle contraction control?
In low Ca2+ levels, tropomyosin inhibits cross-bridge formation
In high Ca2+ levels, Ca2+ binds to troponin, Tropomyosin is displaced, and formation of actin-myosin cross-bridges
What is the difference between troponin and tropomyosin?
tropomyosin is the rope and troponin is the globular proteins that Ca2+ binds to
What is botulinum?
Botulinum toxin blocks acetylcholine release in neuromuscular junctions – body muscles, including the diaphragm, become paralyzed and the victim dies of respiratory failure
What is curare?
Curare blocks acetylcholine from binding to its receptors in muscle fibers – body muscles, including the diaphragm, become paralyzed and the victim dies of respiratory failure
What will a single action potential arriving at a neuromuscular junction causes a single, weak contraction produce?
muscle twitch
What is a twitch summation?
If a muscle fiber is restimulated before it has relaxed completely, the second twitch is added to the first, producing twitch summation