Chapter 43: Anti-Histamine

Question 1

Diphenhydramine MOA and clinical application

Answer 1

H1 receptor INVERSE AGONIST….motion sickness, anaphylaxis, parkinsonism, urticaria, insomnia, allergic rhinitis

= benadryl

Question 2

Dimenhydrinate

Answer 2

Same as diphendrydraminate (benadryl)

Question 3

First generation adverse effects?

Answer 3

midriasis

actual my -dry-eye-isis (dry eyes)

dry mouth

sedation, dizziness, urinary retention/urgency

Question 4

Pyrilamine - first generation, but what is main usage?

Answer 4

Insomnia

Question 5

Promethazine clinical use and MOA

Answer 5

first generation

basically used to relieve preoperative anxiety and nausea

Question 6

Hydroxyzine clinical use and MOA

Answer 6

pruritis

first generation

when something is so itchy you want to pour hydroxy on it

Question 7

Doxepin

Answer 7

tricyclic antidepressant

ironically, can worsen your depression and suicidal thoughts

Question 8

Cetirizine MOA and clinical app

Answer 8

Zyrtec is 2nd generation

allergic rhinits / urticaria

Question 9

Loratadine MOA

Answer 9

2nd generation - claritin

Question 10

Which second generation H1 inverse agonist cannot be used concurrently with MAO inhibitors, severe hypertension and severe coronary artery disease?

Answer 10

Acrivastine

acriVASTine - VAST contraindications

Question 11

Fexofenadine MOA

Answer 11

Allegra first gen

Question 12

Levocabastine cannot be used in people with…

Answer 12

contact lens

Question 13

What drug would you give for vasomotor rhinits and what is the contraindication?

Answer 13

azelastine

dont use with alchohol

Question 14

Olopatide is unique because it can be a ___ administration

Answer 14

topical nasal antihistamine

the nostrils look like Os…OOOOlopadine