Chapter 17: Analgesics Flashcards by Sonya Narla

Q

Morphine

A

Natural or semisynthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

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Q

Codeine

A

Natural or semisynthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

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Q

Oxycodone

A

Natural or semisynthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

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Q

Hydrocodone

A

Natural or semisynthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

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Q

Tramadol

A

Natural or semisynthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

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Q

Methadone

A

Synthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

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Q

Fentanyl

A

Synthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

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Q

Alfentanil

A

Synthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

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Q

Sufentanil

A

Synthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

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Q

Ramifentanil

A

Synthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

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Q

Meperidine

A

Synthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

midriasis - pupils big and wide

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Q

Levorphanol

A

Synthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

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Q

Propoxyphene

A

Synthetic agonists of the μ-opioid receptor that result in inhibition of neurotransmission

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Q

Butorphanol

A

Partial μ-receptor agonist

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Q

Buprenorphine

A

Partial μ-receptor agonist

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Q

Nalbuphine

A

κ-agonist with partial μ-antagonist activity

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Q

Naloxone

A

Antagonists of μ-opioid receptor, thereby blocking endogenous or exogenous opioid effects

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Q

Naltrexone

A

Antagonists of μ-opioid receptor, thereby blocking endogenous or exogenous opioid effects

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Q

Alvimopan

A

Antagonists of μ-opioid receptor, thereby blocking endogenous or exogenous opioid effects

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Q

Methylnaltrexone

A

Antagonists of μ-opioid receptor, thereby blocking endogenous or exogenous opioid effects

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Q

Acetaminophen

A

NSAID - Affect prostaglandin synthetic pathway

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Q

Aspirin

A

NSAID - Affect prostaglandin synthetic pathway

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Q

Naproxen

A

NSAID - Affect prostaglandin synthetic pathway

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Q

Ibuprofen

A

NSAID - Affect prostaglandin synthetic pathway

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Indomethacin

NSAID - Affect prostaglandin synthetic pathway

Diclofenac

NSAID - Affect prostaglandin synthetic pathway

Piroxicam

NSAID - Affect prostaglandin synthetic pathway

Celecoxib

NSAID - Affect prostaglandin synthetic pathway

Diclofenac

NSAID - Affect prostaglandin synthetic pathway

Keterolac

NSAID - Affect prostaglandin synthetic pathway

Amitirptyline

Tricyclic Antodepressant - Promote serotonergic and nonadrenergic neurotransmission by inhibiting neurotransmitter reuptake

Nortriptyline

Tricyclic Antodepressant - Promote serotonergic and nonadrenergic neurotransmission by inhibiting neurotransmitter reuptake

Imipramine

Tricyclic Antodepressant - Promote serotonergic and nonadrenergic neurotransmission by inhibiting neurotransmitter reuptake

Desipramine

Tricyclic Antodepressant - Promote serotonergic and nonadrenergic neurotransmission by inhibiting neurotransmitter reuptake

Duloxetine

Tricyclic Antodepressant - Promote serotonergic and nonadrenergic neurotransmission by inhibiting neurotransmitter reuptake

Venlafaxine

Tricyclic Antodepressant - Promote serotonergic and nonadrenergic neurotransmission by inhibiting neurotransmitter reuptake

Carbamazepine

Antiepileptic Drug or Antiarrythmic - Inhibit action potantial initiation or conduction

Oxcarbazepine

Antiepileptic Drug or Antiarrythmic - Inhibit action potantial initiation or conduction

Gabapentin

Antiepileptic Drug or Antiarrythmic - Inhibit action potantial initiation or conduction

Pregabalin

Antiepileptic Drug or Antiarrythmic - Inhibit action potantial initiation or conduction

Lamotrigine

Antiepileptic Drug or Antiarrythmic - Inhibit action potantial initiation or conduction

Mexiletine

Antiepileptic Drug or Antiarrythmic - Inhibit action potantial initiation or conduction

Ketamine

Blocks NMDA receptor-dependent postsynaptic depolariztion

Dextromethorphan

Blocks NMDA receptor-dependent postsynaptic depolariztion

Sumatriptan

5-HT10 Seretonin Receptor Agonist - Induce cerebrovascular vasoconstriction, reduce nociceptive transmission

Rizatriptan

5-HT10 Seretonin Receptor Agonist - Induce cerebrovascular vasoconstriction, reduce nociceptive transmission

Naratriptan

5-HT10 Seretonin Receptor Agonist - Induce cerebrovascular vasoconstriction, reduce nociceptive transmission

Zolmitriptan

5-HT10 Seretonin Receptor Agonist - Induce cerebrovascular vasoconstriction, reduce nociceptive transmission

Almotriptan

5-HT10 Seretonin Receptor Agonist - Induce cerebrovascular vasoconstriction, reduce nociceptive transmission

Eletriptan

5-HT10 Seretonin Receptor Agonist - Induce cerebrovascular vasoconstriction, reduce nociceptive transmission

Which drugs prevent morphine induced constipation, but have no effect on morphine analgesia?

Alvimopan and Methylnaltrexone

Which drugs do you have to avoid if there is use of a MOAI, in order to avoid seretonin syndrome?

Dextromethorphan and Meperidine

Which drugs active metabolite, M6G, is excreted in the kidney?

Morphine

Which of these drugs is the most potent: Fentanyl, Alfentanil, Sufentanil?

Sufentanil

Which of these drugs is the least potent: Fentanyl, Alfentanil, Sufentanil?

Alfentanil

Due to its long duration of action, which drug is used to achieve long lasting pain relief in cancer patients?

Methadone

Which opioid causes mydriasis rather than miosis?

Meperidine

Which pain control drug may precipitate withdrawl in patients who have received opioids chronically?

Nalbuphine

Which u-opioid receptor agonist has minimal abuse potential?

Tramadol

Which drug has an unusually rapid metabolism and elimination rate?

Ramifentanil

Which drug cannot be given via an epidural or intrathecally, because the glycine in the formulation may cause neurotoxicity?

Ramifentanil

Which drugs produce morphine-like analgesia with milder euphoric effects?

Butorphanol and Buprenorphine

Which drug’s usage is limited due to it’s psychomimetic effects?

Ketamine

Which drug is used for anesthesia, that has minimal risk of respiratory depression?

Ketamine

Which drug is used to treat neuropathic pain as well as the cough?

Dextromethorphan

Which drug can be used to treat opioid and alcohol addiction?

Naltrexone

Which drug can only be used to treat acute oipoid toxicity?

Naloxone