Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Chapter 38: Pharm of Cancer > Flashcards

Chapter 38: Pharm of Cancer Flashcards

1
Q

This drug inhibits thymidylate synthase, thus decreasing availability of dTMP = “thymineless death”

A

Fluorouracil (5-FU)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the orally available prodrug of 5-FU?

A

Capecitabine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

GI cancers, breast cancer, skin cancer like basal cell carcinoma can be treated by this inhibitor of thymidylate synthase….

A

5-FU

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the major adverse effects of 5-FU?

A

myelosuppression

photosensitivity

(atherosclerosis, cerebellar syndrome, vision changes, alopecia, GI probs)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

6-MP effectiveness and toxicity is increased by ______?

A

allopurinol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

6-MP MOA?

A

inhibit IMP dehydrogenase to prevent formation of GMP/AMP by IMP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

6-MP and Azathioprine have the same MOA - which one is used mainly for immunosuppression and which is used mainly for ALL/AML?

A

Immunosupression - azathioprine

ALL/AML - 6-MP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What drug inhibits ribonucleotide reductase? (thus decreasing DNA synthesis…S phase specificty)

A

Hydroxyurea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What does hydroxyurea do in the treatment of sickle cell disease?

A

increases HbF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Drug used in the treatment of myeloprolierative disorders like essential thrombocytosis or polycythemia vera

A

hydroxyurea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the major adverse effects of hydroxyurea?

A

myelosuppression

GI disturbance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

MOA of cyclophosphamide

A

covalently binds DNA…

directly modify DNA structure - alkylating agent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the major adverse effects of cyclophosphamide?

A

Myelosuppression, hemorrhagic cystitis (BLADDER!!!)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

An alkylating agent that is one of the most versatile nitrogen mustards in clinical use. It is a prodrug that must be first activated by hepatic P-450 to produce its active metabolites.

A

Cyclophosphamide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What potentiates the action of 5-FU?

A

Folinic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Super versatile, broad spectrum agent used to treat autoimmune disease, leukemias, lymphomas, mycosis fungoides, neuroblastoma, malignant histiocytosis, and more.

A

cyclophosphamide

17
Q

Alkylating agent that directly binds DNA and is used for the treatment of brain cancer

A

Carmustine

18
Q

Agents that cross link intra-strand guanine bases used in the tx of genitourinary cancers (including testicular), lung cancer….

A

Cisplatin

Carboplatin

19
Q

What are the major adverse effects of cisplatin and carboplatin? Which of these is exclusive to cisplatin?

A

Myelosuppresion, peripheral neuropathy, ototoxicity, nephrotoxicity

Nephrotoxicity - cisplatin only

20
Q

How do you limit the nephrotoxicity of cisplatin?

A

co admin with amifostine

21
Q

Bleomycin MOA?

A

Binds oxygen and chelates iron ….binds DNA –> STRAND BREAKS via generating oxidative intermediates

22
Q

What is the dose limiting side effect of bleomycin?

A

pulmonary fibrosis

irreversible

23
Q

What types of cancers is bleomycin used to treat? Why?

A

Potentially curable cancers because pulmonary fibrosis effect can be so bad

testicular cancer, hodgkins disease, non hodg lymphoma, squamous cell carcinoma

24
Q

Doxorubicin and daunorubicin made adverse effect? MOA?

A

heart failure

inhibit top II - G2 phase of cell cycle

25
Q

What top I inhibitor can cause life threatening diarrhea?

A

TECANS -
irinoTECAN
topoTECAN

26
Q

In giving doxorubicin to a pt with hepatic dysfxn, what must you keep in mind?

A

reduce dosing bc drug is excreted in bile

27
Q

Vinblastine MOA and dose limiting effect?

A

binds tubulin subunits and prevents microtubule polymerization

bone marrow suppression is dose limiting

28
Q

Vincristine MOA and dose limiting effect?

A

binds tubulin subunits and prevents microtubule polymerization

peripheral neuropathy is dose limiting

29
Q

Which drugs come from the peri-winkle plant?

A

vincristine & vinblastine

30
Q

What drug inhibits microtubule DEpolymerization? What is this drug’s dose limiting effect?

A

paclitaxel

peripher neuropathy - stocking/glove sensory loss

31
Q

AIDS related Kaposi sarcoma can be treated by this drug that comes from a western yew tree

A

paclitaxel

Pharmacology (22 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions