Chapter 34 (Staci) Flashcards
_______ may alter the course and pathogenesis of a number of systemic diseases/conditions.
Periodontitis
True or False.
There is evidence that suggesting that periodontitis causes systemic disease.
False
The possibility of an association between periodontal disease and systemic disease suggests that periodontal therapy may play an important role in decreasing the incidence and severity of certain systemic diseases.
______ indicates that there is a relationship or a connection between two or more variables.
Association
If variable A is certain to cause or lead to variable B this would be considered _______.
causation
Periodontitis is characterized by both _____ and ______ events and may contribute to select systemic diseases.
infection and pro-inflammatory
Inflammation, ________ and metastatic infection have been postulated as possible mechanisms of action for linking periodontitis to certain _____ diseases.
the immune response; systemic
_______ is an infectious disease mediated by microorganisms that originate from a distant body site.
Metastatic infection
ex: certain organisms found in the mouth can travel to the lung and possibly cause a lung infection
True or False.
Chewing and tooth brushing can disseminate whole bacteria and their products throughout the body to other nonadjacent organs or body parts.
True
Oral bacteria from ______ lesions and the DNA of certain _______ can survive in the blood stream and adhere to other sites in the body causing systemic disorders.
periodontal; periodontal pathogens
Systemic disorders such as endocarditis, lung infections, abscesses of the brain or liver, and fatty deposits in the carotid arteries can be caused by the _____________ and _______ that can survive in the bloodstream and adhere to other sites in the body.
DNA of periodontal pathogens; oral bacteria
Periodontitis may _____ some aspects of certain systemic diseases to make those diseases more severe.
modify
Infection of the periodontal pocket can stimulate the oral tissues to release _______ mediators which can then enter the blood stream and initiate significant systemic inflammation.
pro-inflammatory
In periodontitis, bacterial _______ are processed and presented to the body’s immune system and recognized by _____.
antigens; lymphocytes
________ inflammation is defined by increased circulation of pro-inflammatory mediators
Systemic
Sub-gingival plaque biofilm provides a large and persistent source of periodontal pathogens that can enter into the systemic blood stream, activating the host immune response which facilitates ______ formation and exacerbation.
atheroma
True or False.
The correlation between metastatic infection as well as inflammation and immune response have all been postulated as possible mechanisms of action for linking periodontitis to certain systemic diseases.
True
Which of the following is NOT one of the possible biologic explanations for the correlation between ACVD and periodontitis?
A. Dyslipidemia
B. Elevated levels of fibrinogen
C. Antibody Cross Reactivity
D. Reduced Systemic Inflammation
D. Reduced Systemic Inflammation
Correct Answer: Heightened Systemic Inflammation
Periodontal infections may contribute to atherosclerosis by triggering the host to produce elevated levels of serum ______, as well as low-density lipoproteins, _____, and very low-density lipoproteins.
cholesterol; triglycerides
Periodontitis elevates levels of ________ which increases vascular inflammation. This is important because the coagulation and fibrinolytic systems play important roles in the thickening of the arteries and clot formation.
fibrinogen
True or False
Studies have shown that patient with periodontitis have lower levels of plasma fibrinogen
False
they have HIGHER levels of fibrinogen
_______ , one of the possible biologic explanations for the correlation between ACVD and periodontitis, occurs when an antibody reacts with an antigen other than the one that initially induced it’s production.
Cross reactivity
Patients with periodontitis have elevated systemic antibody responses to a variety of _______ and are able to induce antibody cross reactivity.
periodontal microorganisms
True or False.
*Cross-reactivity suggests that periodontal pathogens induce the body’s immune response to mistakenly target cells in blood vessels leading to vascular inflammation and atherosclerosis.
True
Atherscherotic cardiovascular disease (ACVD) is a group of heart or vascular diseases including
A. angina, myocardial infarction, asthma, transient ischemic attack, and peripheral artery disease
B. angina, myocardial infarction, stroke, transient ischemic attack, and peripheral artery disease
C. angina, myocardial infarction, rheumatoid arthritis, transient ischemic attack, and peripheral artery disease
A. angina, myocardial infarction, stroke, transient ischemic attack, and peripheral artery disease
_______ is characterized by a thickening of arterial walls.
Atherosclerosis