Chapter 32 Flashcards
In the presence of oxygen, the _________ effect is amplified with _______ LET radiation.
indirect, low
Which of the following is true regarding the multi-target model of cell lethality?
a. The critical target is considered to be the cells RNA.
b. Cells have more than one critical target, each of which has to be inactivated for cell death to occur.
c. The cell can accumulate radiation dose.
d. Only cell death can be measured with accuracy.
Cells have more than one critical target, each of which has to be inactivated for cell death to occur.
Which of the following statement(s) is/are true about target theory?
- The key sensitive target molecule is DNA.
- Hits occur only by indirect effect.
- Radiation interaction with the targets is random.
1 & 3
Which of the following phases of the cell cycle is considered most radioresistant?
a. M phase
b. late S phase
c. G1 phase
d. I phase
late S phase
Irradiating human cells with a high LET radiation follows which model?
Single target, single hit
T/F: The lethal effects of cell irradiation are measured by cell death.
False
Measured by cell survival
Oxygen would enhance the effects of which type of radiation the most?
xray
When irradiated with x rays, human cells follow which model?
Multi-target, single-hit model
T/F: The effect oxygen has on high LET radiation is considered irrelevant.
True
This term is related to a cell’s capacity to recover from a sublethal dose.
DQ
This term is referred to as the threshold dose.
DQ
This term is represented by the width of the shoulder on a multi-target, single-hit curve.
DQ
This term is the dose necessary to reduce the survival rate of a cell population to the equivalent of D37.
D0
This term is a statistical measure that refers to a radiation dose level sufficient enough to kill 63% of cells in a population.
D37
This term is constant to cell radiosensitivity.
D0
