Chapter 30: Ventilation and Gas Exchange Flashcards
Hypoxemia
reduction in arterial blood oxygen levels
PaO2 < 80 mmHg
3 ways body compensates for chronic hypoxemia
1) increasing ventilation
2) pulmonary vasoconstriction (improves V/Q ratio)
3) increased production of RBCs (O2 carrying capacity)
______ is a late sign of hypoxemia and can be central or peripheral
CYANOSIS
Central: oral mucosa and lips
Peripheral: nailbeds, nose, or ears
________ provides a direct measure of O2 content in blood and is the best indicator of lung’s ability to oxygenate blood
ABGs
Pulse oximeter is unable to distinguish between ___________
oxygen-carrying Hgb and carbon-monoxide-carrying Hgb
Hypercapnia
increase in CO2 content of arterial blood
3 causes of hypercapnia
1) hypoventilation
2) increase in metabolic rate (fever, exercise)
3) high-carb diet
Obstructive Lung Disorders
increase in resistance to airflow - harder to get air out (increased compliance)
asthma, emphysema, COPD
Restrictive Lung Disorders
reduced expansion of lung tissue with decreased total lung capacity
harder to get air in (decreased compliance)
sarcoidosis, pulmonary fibrosis
Obstructive lung disorders attempt to maintain minute volume by ________ _______ breathing
slow, deep breathing
Restrictive lung disorders attempt to maintain minute volume by ________ _______ breathing
rapid, shallow breathing
Sarcoidosis
restrictive lung disorder in which granulomas are in found in affected tissue and and organ systems
Most common locations for clinical manifestations in sarcoidosis (4)
lungs
skin
eyes
neurological system
Clinical Manifestations of Sarcoidosis
dry, nonproductive cough and SOB
papules and plaques on skin
uveitis
weakness of CN VII = Bells Palsy
Asthma
hyper-reactive (obstructive) airway disease
chronic inflammatory disease that causes episodes of spastic reactivity in the bronchioles
Asthma is characterized by __________ (3)
reversible airway bronchospasm (early) mucus hypersecretion (late) bronchial edema (late)
Immune Cells Involved in ASTHMA (3)
T-helper cells = Th1 and Th2
IgE
Th1
stimulated by microbes or allergens
assists B-lymphocytes to transform into plasma cells (IgE)
Th2
attract mast cells, eosinophils, and basophils = promote inflammation
IgE in Asthma
Allergen binds to IgE
IgE binds to mast cells and provokes degranulation = chemical mediators
Chemical Mediators Released by Mast Cells in Asthma (4)
1) histamine
2) prostaglandins
3) leukotrienes
4) bradykinin
Histamine
attaches to receptor sites in larger cronhi causing swelling and contraction of the smooth muscles
stimulates the mucous membranes to secrete excessive mucus (further narrows the bronchial lumen)
Air trapping is a result of ________ on exhalation (in asthma)
increased intrathoracic pressure that closes the narrowed bronchial lumen completely
Prostaglandins
derived from arachidonic acid - uses the cyclooxygenase pathway
enhances the action of histamine