chapter 3 rational drug selection Flashcards
1
Q
the I Can PresCribE A Drug mnemonic
A
Indication Contraindications Precautions Cost/Compliance Efficacy Adverse effects Dose/Duration/Direction
2
Q
factors influencing drug selection
A
pharmacokinetic: bioavailability, CYP 450 metabolism, renal clearance/elimination, dose-concentration curve, half-life
pharmacodynamic: ease of titration, therapeutic index (time period when working the most-deals with dosing)
therapeutic: evidence supporting impact
safety: profile varies by population (i.e.teratogens-effecting embryos, drug allergies etc.), FDA advisories
cost: to patient, cost to health system
patient: pmhx, current drug tx, age, pregnancy/breast feeding, co-morbidities
provider: ease of prescribing/monitoring, formularies
- alternative therapies
3
Q
process of drug prescribing
A
- define pt’s problem
- specify therapeutic goal
- collaborate with pt
- choose tx
- educate pt
- monitor effectiveness
