chapter 24 tetracycline

Question 1

pharmacodynamics/pharmacokinetics of tetracycline

Answer 1

• bind reversibly to bacterial subunit
• food-especially milk (calcium) decreases absorption
• many drug interactions

Question 2

clinical use of tetracylines

Answer 2

• doxycycline-1st line for c. trachomatis and ureaplasma urealyticum (Lymes dz, rocky mountain spotted fever)
• tetracycline and minocycline for p. acnes
• h. pylori regimens incl. tetracycline
• doxycycline and minocycline can be taken with food

Question 3

tetracycline

Answer 3

• broad spectrum abx
• not first line because of many food-drug reactions
• can be po or topical
• don’t prescribe for pregnant women of children