Chapter 3 Flashcards
Clevage
Zygote undergoes rapid mitotic cell divisions
Two types:
1. Indeterminate
2. Determinate
Indeterminate Clevage
Cell divission where cells can differentiate into any cell type or a whole organism
Determinate Clevage
Cell division in cells having definitive lineages
* AT LEAST 1 daughter cell is commited to diffferenting into certain type of cell
Stages of Development
Zygote: 2-, 4-, 8-
16-Cell Embryo > morula > blastula/blastocyst (implantation occurs) > gastrula
Primary Germ Layers
- Ectoderm (outermost layer)
- Mesoderm (middle layer)
- Endoderm (innermost layer)
Ectoderm
Organs:
* Integument (epidermis, hair, nails, epithelia of nose, mouth, anal canal)
* Lens of eye
* Nervous system (adrenal medulla)
* Inner ear
Mesoderm
Organs:
* Musculoskeletal system
* Circulatory system
* Excretory system
* Gonads
* Muscular and connective tissue layers of digestive and respiratory systems
* Adrenal Cortex
* Notochord: Rod of mesodermal cells that develop along longitudinal axis under dorsal layer of ectoderm
Endoderm
Organs:
* Epithelial linings of digestive and respiratory tracts
* Parts of liver
* Pancreas
* Thyroid
* Bladder
* Distal urinary and reproductive tracts
Induction
Nearby cells influence differentiation of adjacent cells
* Ensures proper spatial location and orientation of cells sharing/complementary functions
* Mediated by influencers (chemicals) that diffuse from organizing cells to responsive cells
Neural Crest Cells
- Become peripheral nervous system (sensory ganglia, autonomic ganglia, adrenal medulla, Schwann cells)
- Specific cell types in other tissues (calcitonin-producing cells of thyroid, melanocytes in skin)
Determination
Commitment of a cell to a particular lineage
* Presence of specific mRNA and protein molecules may result in determination
* May occur from secretion of morphogens (specific molecules from nearby cells)
* Hasn’t produced products needed to carry out functions of cell type
* If fails will lead to absence of structure
Differentiation
Actual changes that occur for the cell to assume structure/function/biochemistry of determined cell type
* If fails leads to absence of structure
Stem Cells
Cells that haven’t differentiated that lead to other cells that will differentiate
* Thought that can regenerate human tissues (ex: spinal chord and cardiac myocytes)
Potency
What determines the tissues a certain stem cell can differentiate into
3 Types:
1. Totipotent
2. Pluripotent
3. Multipotent
Totipotent
Any cell type in the developing embryo (primary germ layers) or inextraembryonic tissues (amnion, chorion, placenta)
* Cells with greatest potency
* Embryonic stem cells
* Can differentiate into any cell type in fetus/placental structure